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• W1698949934 abstract "Estrogens are reported to increase type I and type III collagen deposition and to regulate Metalloproteinase 2 (MMP-2) expression. These proteins are reported to be dysregulated in incisional hernia formation resulting in a significantly decreased type I to III ratio. We aimed to evaluate the β-estradiol mediated regulation of type I and type III collagen genes as well as MMP-2 gene expression in fibroblasts derived from patients with or without history of recurrent incisional hernia disease. We compared primary fibroblast cultures from male/female subjects without/without incisional hernia disease. Incisional hernia fibroblasts (IHFs) revealed a decreased type I/III collagen mRNA ratio. Whereas fibroblasts from healthy female donors responded to β-estradiol, type I and type III gene transcription is not affected in fibroblasts from males or affected females. Furthermore β-estradiol had no influence on the impaired type I to III collagen ratio in fibroblasts from recurrent hernia patients. Our results suggest that β-estradiol does not restore the imbaired balance of type I/III collagen in incisional hernia fibroblasts. Furthermore, the individual was identified as an independent factor for the β-estradiol induced alterations of collagen gene expression. The observation of gender specific β-estradiol-dependent changes of collagen gene expression in vitro is of significance for future studies of cellular response." @default.
• W1698949934 created "2016-06-24" @default.
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• W1698949934 date "2006-09-29" @default.
• W1698949934 modified "2023-09-25" @default.
• W1698949934 title "Hernia fibroblasts lack β-estradiol induced alterations of collagen gene expression" @default.
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• W1698949934 doi "https://doi.org/10.1186/1471-2121-7-36" @default.
• W1698949934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1594569" @default.
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