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• W1699841916 endingPage "4073" @default.
• W1699841916 startingPage "4067" @default.
• W1699841916 abstract "Abstract Adhesion of Langerhans cells (LC) to keratinocytes is mediated by E-cadherin. IL-1, TNF-α, and LPS mobilize LC from epidermis and presumably attenuate LC-keratinocyte adhesion. To determine whether these mediators modulated LC E-cadherin-dependent adhesion directly, we characterized their effects on LC-like dendritic cells expanded from murine fetal skin (FSDDC). FSDDC were propagated from day 16 C57BL/6 fetal skin and isolated as aggregates (FSDDC-A) in which homophilic adhesion was mediated by E-cadherin. IL-1, TNF-α, and LPS induced dissociation of FSDDC-A that began within 4 to 8 h and was complete within 20 h. Anti-IL-1RI mAb inhibited disaggregation caused by IL-1α and IL-1β, but not that induced by TNF-α or LPS. Anti-TNF-α mAb inhibited the effect of TNF-α and LPS, but not that caused by IL-1α or IL-1β. Flow cytometry of FSDDC-A revealed that IL-1, TNF-α, and LPS induced increased expression of MHC class II, CD40, and CD86 and decreased E-cadherin expression that was temporally related to dissociation of aggregates. IL-1 and TNF-α caused a rapid reduction in FSDDC E-cadherin mRNA levels that preceded the decrease in E-cadherin surface expression. These results demonstrate that cytokines that induce LC emigration in vivo act directly on LC-like cells in vitro, reduce E-cadherin mRNA levels, down-regulate E-cadherin surface expression, and induce a loss of E-cadherin-mediated adhesion." @default.
• W1699841916 created "2016-06-24" @default.
• W1699841916 creator A5037651981 @default.
• W1699841916 creator A5044791487 @default.
• W1699841916 date "1998-04-15" @default.
• W1699841916 modified "2023-10-18" @default.
• W1699841916 title "Regulation of E-Cadherin-Mediated Adhesion in Langerhans Cell-Like Dendritic Cells by Inflammatory Mediators That Mobilize Langerhans Cells In Vivo" @default.
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• W1699841916 doi "https://doi.org/10.4049/jimmunol.160.8.4067" @default.
• W1699841916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9558117" @default.
• W1699841916 hasPublicationYear "1998" @default.
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