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- W170006903 abstract "Murine, human, and chimeric monoclonal antibodies (MoAb) are currently being used as toxin and radionuclide-immunoconjugates for the treatment of autoimmune disease, graft rejection, and cancer. Although these immunoconjugates have considerable potential, problems associated with their toxicity have slowed their clinical application. Unconjugated MoAb, although not associated with as severe side effects, have generally had little biological activity in vivo. This is probably because most MoAb do not efficiently initiate host cellular or humoral effector mechanisms. For a MoAb to be an effective therapeutic agent, it must work in concert with the human complement system and/or with cytotoxic trigger molecules on effector cells. For example, in antibody-dependent cellular cytotoxicity (ADCC), killing of the target cell is triggered when Fc receptors for IgG (FcyR) on effector cells are crosslinked, leading to the directed release of cytotoxic molecules from the effector cell. Many potentially useful MoAb are not of the appropriate isotype, and therefore are unable to activate human complement and/or trigger FcyR on human cells." @default.
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- W170006903 date "1993-01-01" @default.
- W170006903 modified "2023-09-25" @default.
- W170006903 title "Use of bispecific antibodies in the therapy of tumors" @default.
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- W170006903 doi "https://doi.org/10.1007/978-1-4615-3076-3_10" @default.
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