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- W170070488 endingPage "489" @default.
- W170070488 startingPage "469" @default.
- W170070488 abstract "The development of cancer has been shown to occur through a process of malignant transformation that involves a series of genetic changes that provide a selective advantage over normal cells, and research over the past few decades has identified numerous genes and pathways involved in all stages of tumor progression. These genetic changes invariably disrupt fundamental cellular processes controlling proliferation, apoptosis, differentiation, and genome stability, and it is the combinatorial effect of these genetic changes that result in malignant transformation. Proliferating hematopoietic and epithelial cell populations are particularly susceptible to accumulation of a series of genetic changes required for full-blown malignancy, and nearly 90% of all human solid tumors arise from epithelial cells. The majority of patients who succumb to cancer die as a result of metastatic disease progression rather than from the primary tumor. The process of metastasis is extremely complex, and involves many steps including dissemination of tumor cells from the primary tumor through the vascular and lymphatic system coupled with the ability to colonize selectively distant tissues and organs. The pleiotropic cytokine transforming growth factor-β and its signaling effectors have been shown to be involved at numerous steps in the development of cancer. The role of transforming growth factor-β signaling in cancer is complex, with biphasic functions as a tumor suppressor in normal tissue and early-stage lesions and as a prometastatic agent in latestage disease." @default.
- W170070488 created "2016-06-24" @default.
- W170070488 creator A5040137655 @default.
- W170070488 creator A5050064612 @default.
- W170070488 date "2007-11-08" @default.
- W170070488 modified "2023-09-25" @default.
- W170070488 title "Role of TGF-β in Tumor Progression and Metastasis" @default.
- W170070488 cites W115277085 @default.
- W170070488 cites W1483423516 @default.
- W170070488 cites W1486555624 @default.
- W170070488 cites W1503228526 @default.
- W170070488 cites W1506807751 @default.
- W170070488 cites W1521598031 @default.
- W170070488 cites W1524114372 @default.
- W170070488 cites W1529983307 @default.
- W170070488 cites W1538328956 @default.
- W170070488 cites W1571796034 @default.
- W170070488 cites W1575754639 @default.
- W170070488 cites W1587849076 @default.
- W170070488 cites W1597704353 @default.
- W170070488 cites W1598137584 @default.
- W170070488 cites W1619959770 @default.
- W170070488 cites W1930083400 @default.
- W170070488 cites W1965568495 @default.
- W170070488 cites W1967502057 @default.
- W170070488 cites W1968070070 @default.
- W170070488 cites W1968090694 @default.
- W170070488 cites W1969672566 @default.
- W170070488 cites W1970284437 @default.
- W170070488 cites W1971439358 @default.
- W170070488 cites W1972535098 @default.
- W170070488 cites W1973614487 @default.
- W170070488 cites W1974571648 @default.
- W170070488 cites W1974955986 @default.
- W170070488 cites W1975600980 @default.
- W170070488 cites W1980448977 @default.
- W170070488 cites W1981040379 @default.
- W170070488 cites W1982093899 @default.
- W170070488 cites W1982422189 @default.
- W170070488 cites W1983075270 @default.
- W170070488 cites W1983628734 @default.
- W170070488 cites W1984100287 @default.
- W170070488 cites W1985400766 @default.
- W170070488 cites W1985929046 @default.
- W170070488 cites W1986471913 @default.
- W170070488 cites W1986666543 @default.
- W170070488 cites W1988916713 @default.
- W170070488 cites W1994560336 @default.
- W170070488 cites W1995746818 @default.
- W170070488 cites W1998753830 @default.
- W170070488 cites W1998975199 @default.
- W170070488 cites W1999086610 @default.
- W170070488 cites W1999095939 @default.
- W170070488 cites W2002621910 @default.
- W170070488 cites W2002801575 @default.
- W170070488 cites W2002946136 @default.
- W170070488 cites W2005113904 @default.
- W170070488 cites W2005328425 @default.
- W170070488 cites W2005472560 @default.
- W170070488 cites W2006005116 @default.
- W170070488 cites W2007044718 @default.
- W170070488 cites W2007897263 @default.
- W170070488 cites W2011912935 @default.
- W170070488 cites W2012124753 @default.
- W170070488 cites W2014476883 @default.
- W170070488 cites W2015784235 @default.
- W170070488 cites W2015959969 @default.
- W170070488 cites W2016920291 @default.
- W170070488 cites W2017201371 @default.
- W170070488 cites W2018075165 @default.
- W170070488 cites W2019242560 @default.
- W170070488 cites W2019788712 @default.
- W170070488 cites W2023468848 @default.
- W170070488 cites W2023961961 @default.
- W170070488 cites W2024065989 @default.
- W170070488 cites W2026460094 @default.
- W170070488 cites W2026545194 @default.
- W170070488 cites W2027275036 @default.
- W170070488 cites W2028911827 @default.
- W170070488 cites W2030798978 @default.
- W170070488 cites W2030918894 @default.
- W170070488 cites W2032622848 @default.
- W170070488 cites W2033973727 @default.
- W170070488 cites W2035653659 @default.
- W170070488 cites W2036148210 @default.
- W170070488 cites W2037038224 @default.
- W170070488 cites W2037787006 @default.
- W170070488 cites W2037973994 @default.
- W170070488 cites W2039275948 @default.
- W170070488 cites W2039347592 @default.
- W170070488 cites W2040074251 @default.
- W170070488 cites W2041154504 @default.
- W170070488 cites W2041491142 @default.
- W170070488 cites W2042773343 @default.
- W170070488 cites W2042808830 @default.
- W170070488 cites W2043164695 @default.
- W170070488 cites W2044069347 @default.
- W170070488 cites W2048295637 @default.