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- W17007487 abstract "Protein phosphatases play significant roles in signal transduction pathways that regulate cellular processes in response to external/internal stimuli. They are crucial for the growth, division, and differentiation of all organisms. Examples of cell functions involving reversible phosphorylation include ion transport, metabolism, cell cycle progression, developmental control, and stress responses. Serine/threoninespecific protein phosphatases are of particular interest in this study. There are two types of serine/threonine-specific protein phosphatases: type 1 & type 2. Both protein phosphatase 1 (PPl) and protein phosphatase 2A (PP2A) are inhibited by a structurally diverse group of natural toxins produced by marine organisms that cause diarrhetic shellfish poisoning. Recent research into diarrhetic shellfish poisoning has contributed to the understanding of some of the mechanism of actions of cathartics. It was learned that hydroxy acid moieties are essential for receptor binding of diarrhetic shellfish toxins, such as okadaic acid, to the protein phosphatase enzymes in the intestines which regulate ion channels. The loss of ion channel regulation in the intestines leads to an efflux of electrolytes and water, causing diarrhea." @default.
- W17007487 created "2016-06-24" @default.
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- W17007487 date "2020-06-10" @default.
- W17007487 modified "2023-10-18" @default.
- W17007487 title "INHIBITION STUDIES OF PROTEIN PHOSPHATASE 2A BY KNOWN CATHARTIC PLANT DRUGS" @default.
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- W17007487 doi "https://doi.org/10.23860/thesis-ford-michael-2001" @default.
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