FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1701296509> ?p ?o ?g. }

• W1701296509 endingPage "12" @default.
• W1701296509 startingPage "505" @default.
• W1701296509 abstract "The strategies for achieving anti-metastasis have received increased research interest and clinical attention. The anoikis-sensitizing effect of ecteinascidin 770 (ET-770) was investigated in the present study in non-small cell lung cancer cells.ET-770 isolated from Ecteinascidia thurstoni was tested for its anoikis-sensitizing effect on H23 and H460 human lung cancer cells by 2,3-b-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide salt (XTT) assay. The levels of proteins being involved in anoikis of cells were determined by western blot analysis.ET-770 was shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. The underlying mechanism was investigated and it was found that ET-770 sensitized the cells by activating the p53 protein, which in turn down-regulated anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulated BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins were not significantly affected by ET-770. Further, the anoikis sensitization of ET-770 was observed in H460 lung cancer cells.The present results reveal for the first time that ET-770 can sensitize anoikis through the p53 pathway and further development of this compound for therapeutic use is warranted." @default.
• W1701296509 created "2016-06-24" @default.
• W1701296509 creator A5019794851 @default.
• W1701296509 creator A5046242061 @default.
• W1701296509 creator A5056141814 @default.
• W1701296509 creator A5068749362 @default.
• W1701296509 date "2013-02-01" @default.
• W1701296509 modified "2023-09-23" @default.
• W1701296509 title "Ecteinascidin 770, a tetrahydroisoquinoline alkaloid, sensitizes human lung cancer cells to anoikis." @default.
• W1701296509 cites W1629453516 @default.
• W1701296509 cites W1969909442 @default.
• W1701296509 cites W1972361063 @default.
• W1701296509 cites W1981466043 @default.
• W1701296509 cites W1984069764 @default.
• W1701296509 cites W1985385147 @default.
• W1701296509 cites W1992947847 @default.
• W1701296509 cites W2011180826 @default.
• W1701296509 cites W2012835470 @default.
• W1701296509 cites W2034269086 @default.
• W1701296509 cites W2058606676 @default.
• W1701296509 cites W2060561842 @default.
• W1701296509 cites W2062547838 @default.
• W1701296509 cites W2064937772 @default.
• W1701296509 cites W2079449116 @default.
• W1701296509 cites W2081894694 @default.
• W1701296509 cites W2085131862 @default.
• W1701296509 cites W2087065324 @default.
• W1701296509 cites W2088009631 @default.
• W1701296509 cites W2089448176 @default.
• W1701296509 cites W2091823826 @default.
• W1701296509 cites W2103616303 @default.
• W1701296509 cites W2110891275 @default.
• W1701296509 cites W2114858260 @default.
• W1701296509 cites W2117131451 @default.
• W1701296509 cites W2124580184 @default.
• W1701296509 cites W2125988618 @default.
• W1701296509 cites W2127159062 @default.
• W1701296509 cites W2128854316 @default.
• W1701296509 cites W2137022580 @default.
• W1701296509 cites W2142977207 @default.
• W1701296509 cites W2144284013 @default.
• W1701296509 cites W2144884298 @default.
• W1701296509 cites W2145139438 @default.
• W1701296509 cites W2151960655 @default.
• W1701296509 cites W2170492618 @default.
• W1701296509 cites W2187914961 @default.
• W1701296509 cites W2346349612 @default.
• W1701296509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23393342" @default.
• W1701296509 hasPublicationYear "2013" @default.
• W1701296509 type Work @default.
• W1701296509 sameAs 1701296509 @default.
• W1701296509 citedByCount "6" @default.
• W1701296509 countsByYear W17012965092013 @default.
• W1701296509 countsByYear W17012965092014 @default.
• W1701296509 countsByYear W17012965092017 @default.
• W1701296509 countsByYear W17012965092022 @default.
• W1701296509 crossrefType "journal-article" @default.
• W1701296509 hasAuthorship W1701296509A5019794851 @default.
• W1701296509 hasAuthorship W1701296509A5046242061 @default.
• W1701296509 hasAuthorship W1701296509A5056141814 @default.
• W1701296509 hasAuthorship W1701296509A5068749362 @default.
• W1701296509 hasConcept C121608353 @default.
• W1701296509 hasConcept C143998085 @default.
• W1701296509 hasConcept C1491633281 @default.
• W1701296509 hasConcept C152000582 @default.
• W1701296509 hasConcept C185592680 @default.
• W1701296509 hasConcept C190283241 @default.
• W1701296509 hasConcept C203014093 @default.
• W1701296509 hasConcept C2776256026 @default.
• W1701296509 hasConcept C2779013556 @default.
• W1701296509 hasConcept C502942594 @default.
• W1701296509 hasConcept C54355233 @default.
• W1701296509 hasConcept C55493867 @default.
• W1701296509 hasConcept C62112901 @default.
• W1701296509 hasConcept C71924100 @default.
• W1701296509 hasConcept C86803240 @default.
• W1701296509 hasConcept C96232424 @default.
• W1701296509 hasConcept C98274493 @default.
• W1701296509 hasConceptScore W1701296509C121608353 @default.
• W1701296509 hasConceptScore W1701296509C143998085 @default.
• W1701296509 hasConceptScore W1701296509C1491633281 @default.
• W1701296509 hasConceptScore W1701296509C152000582 @default.
• W1701296509 hasConceptScore W1701296509C185592680 @default.
• W1701296509 hasConceptScore W1701296509C190283241 @default.
• W1701296509 hasConceptScore W1701296509C203014093 @default.
• W1701296509 hasConceptScore W1701296509C2776256026 @default.
• W1701296509 hasConceptScore W1701296509C2779013556 @default.
• W1701296509 hasConceptScore W1701296509C502942594 @default.
• W1701296509 hasConceptScore W1701296509C54355233 @default.
• W1701296509 hasConceptScore W1701296509C55493867 @default.
• W1701296509 hasConceptScore W1701296509C62112901 @default.
• W1701296509 hasConceptScore W1701296509C71924100 @default.
• W1701296509 hasConceptScore W1701296509C86803240 @default.
• W1701296509 hasConceptScore W1701296509C96232424 @default.
• W1701296509 hasConceptScore W1701296509C98274493 @default.
• W1701296509 hasIssue "2" @default.
• W1701296509 hasLocation W17012965091 @default.
• W1701296509 hasOpenAccess W1701296509 @default.

• next