Matches in SemOpenAlex for { <https://semopenalex.org/work/W170153895> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W170153895 abstract "In a scant few years, the ligand-stimulated turnover of phosphatidylinositol (PI) has progressed from a curious observation to a major biochemical and pharmacological enterprise. In the 1940’s, de Hevesy (see de Hevesy, 1964) introduced the use of beta-emitting radioisotopes to biochemistry, and demonstrated that the addition of 32P-labeled inorganic phosphate to tissue preparations led to highly radioactive phospholipids. In 1953, Hokin and Hokin published their seminal observation that two minor phospholipids, phosphatidylinositol (PI) and phosphatidate (PA) were selectively labeled to high specific activities in such preparations (Hokin and Hokin, 1953). Furthermore, the labeling was greatly intensified by the presence of cholinergic ligands in the incubation medium, and the stimulated labeling could be reduced to the basal level by the addition of atropine, a known antagonist of muscarinic cholinergic receptors. This latter observation was important, since it demonstrated that the stimulated labeling is indeed receptor-linked. Hence their observation constituted a biochemical “handle” into the transduction process whereby a receptor-ligand interaction on the outer leaflet of the plasma membrane is converted to an intracellular response. Over the intervening years, it became apparent that a large number of receptor-ligand interactions could be coupled to stimulated PA and PI labeling, and that they formed a class distinct from receptor-ligand interactions linked to cyclic AMP." @default.
- W170153895 created "2016-06-24" @default.
- W170153895 creator A5075022269 @default.
- W170153895 date "1987-01-01" @default.
- W170153895 modified "2023-09-27" @default.
- W170153895 title "Receptor-Mediated Phosphoinositide Metabolism" @default.
- W170153895 cites W1802980406 @default.
- W170153895 cites W1889236699 @default.
- W170153895 cites W1976781991 @default.
- W170153895 cites W1983085304 @default.
- W170153895 cites W1998490733 @default.
- W170153895 cites W2014107460 @default.
- W170153895 cites W2027704731 @default.
- W170153895 cites W2030664952 @default.
- W170153895 cites W2050923935 @default.
- W170153895 cites W2052637656 @default.
- W170153895 cites W2067401626 @default.
- W170153895 cites W2072099683 @default.
- W170153895 cites W2077853992 @default.
- W170153895 cites W2092134407 @default.
- W170153895 cites W2103418001 @default.
- W170153895 cites W2153696262 @default.
- W170153895 cites W2214267384 @default.
- W170153895 cites W2263541816 @default.
- W170153895 cites W2490962737 @default.
- W170153895 cites W4298876807 @default.
- W170153895 doi "https://doi.org/10.1007/978-1-4684-7618-7_5" @default.
- W170153895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2829592" @default.
- W170153895 hasPublicationYear "1987" @default.
- W170153895 type Work @default.
- W170153895 sameAs 170153895 @default.
- W170153895 citedByCount "2" @default.
- W170153895 crossrefType "book-chapter" @default.
- W170153895 hasAuthorship W170153895A5075022269 @default.
- W170153895 hasConcept C116289061 @default.
- W170153895 hasConcept C116569031 @default.
- W170153895 hasConcept C12554922 @default.
- W170153895 hasConcept C134018914 @default.
- W170153895 hasConcept C163235415 @default.
- W170153895 hasConcept C170493617 @default.
- W170153895 hasConcept C185592680 @default.
- W170153895 hasConcept C22885893 @default.
- W170153895 hasConcept C2776909261 @default.
- W170153895 hasConcept C2778918659 @default.
- W170153895 hasConcept C2780610907 @default.
- W170153895 hasConcept C2909482567 @default.
- W170153895 hasConcept C33789571 @default.
- W170153895 hasConcept C41625074 @default.
- W170153895 hasConcept C53009064 @default.
- W170153895 hasConcept C55493867 @default.
- W170153895 hasConcept C62478195 @default.
- W170153895 hasConcept C64615621 @default.
- W170153895 hasConcept C79879829 @default.
- W170153895 hasConcept C86803240 @default.
- W170153895 hasConcept C95444343 @default.
- W170153895 hasConceptScore W170153895C116289061 @default.
- W170153895 hasConceptScore W170153895C116569031 @default.
- W170153895 hasConceptScore W170153895C12554922 @default.
- W170153895 hasConceptScore W170153895C134018914 @default.
- W170153895 hasConceptScore W170153895C163235415 @default.
- W170153895 hasConceptScore W170153895C170493617 @default.
- W170153895 hasConceptScore W170153895C185592680 @default.
- W170153895 hasConceptScore W170153895C22885893 @default.
- W170153895 hasConceptScore W170153895C2776909261 @default.
- W170153895 hasConceptScore W170153895C2778918659 @default.
- W170153895 hasConceptScore W170153895C2780610907 @default.
- W170153895 hasConceptScore W170153895C2909482567 @default.
- W170153895 hasConceptScore W170153895C33789571 @default.
- W170153895 hasConceptScore W170153895C41625074 @default.
- W170153895 hasConceptScore W170153895C53009064 @default.
- W170153895 hasConceptScore W170153895C55493867 @default.
- W170153895 hasConceptScore W170153895C62478195 @default.
- W170153895 hasConceptScore W170153895C64615621 @default.
- W170153895 hasConceptScore W170153895C79879829 @default.
- W170153895 hasConceptScore W170153895C86803240 @default.
- W170153895 hasConceptScore W170153895C95444343 @default.
- W170153895 hasLocation W1701538951 @default.
- W170153895 hasLocation W1701538952 @default.
- W170153895 hasOpenAccess W170153895 @default.
- W170153895 hasPrimaryLocation W1701538951 @default.
- W170153895 hasRelatedWork W1555974577 @default.
- W170153895 hasRelatedWork W170153895 @default.
- W170153895 hasRelatedWork W185435004 @default.
- W170153895 hasRelatedWork W2016287718 @default.
- W170153895 hasRelatedWork W2032318679 @default.
- W170153895 hasRelatedWork W2050751344 @default.
- W170153895 hasRelatedWork W2060584742 @default.
- W170153895 hasRelatedWork W2214926170 @default.
- W170153895 hasRelatedWork W6381687 @default.
- W170153895 hasRelatedWork W74104533 @default.
- W170153895 isParatext "false" @default.
- W170153895 isRetracted "false" @default.
- W170153895 magId "170153895" @default.
- W170153895 workType "book-chapter" @default.