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- W170233036 endingPage "57" @default.
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- W170233036 abstract "A successful axonal response to injury requires retrograde signaling to induce changes in the cell body response, and mobilization of outgrowth programs while integrating growth-promoting and growth-inhibiting signals from the environment. Central nervous system (CNS) and peripheral nervous system (PNS) axons differ in their capacity for useful regeneration, most likely due to differences in intrinsic growth capacity coupled with differential composition of extracellular growth-modulating agents in central versus peripheral environments. Very recent studies have demonstrated marked increases in growth rates of injured CNS axons using combinatorial manipulations of the environment together with re-activation of intrinsic growth programs. This chapter reviews progress on understanding the different mechanistic aspects of the axonal response to injury, with particular focus on mechanisms of activation of intrinsic growth programs, and on the gaps in knowledge that must be bridged for stimulating effective axon re-growth." @default.
- W170233036 created "2016-06-24" @default.
- W170233036 creator A5065355117 @default.
- W170233036 date "2008-01-01" @default.
- W170233036 modified "2023-09-27" @default.
- W170233036 title "AXONAL RESPONSES TO INJURY" @default.
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- W170233036 doi "https://doi.org/10.1016/b978-012373994-0.50004-x" @default.
- W170233036 hasPublicationYear "2008" @default.
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