FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W170263297> ?p ?o ?g. }

• W170263297 endingPage "212" @default.
• W170263297 startingPage "199" @default.
• W170263297 abstract "Patients with dilated cardiomyopathy and implantable cardioverter-defibrillator (ICD) are a high-risk group for arrhythmias. They regularly undergo cardiopulmonary exercise testing (CPET) to assess cardiac reserve and to guide clinical decisions or therapeutic adjustments. Data from previous studies demonstrate that prognosis in patients with heart failure (HF) worsens with the presence of appropriate shocks.The purpose of this study was to evaluate the value of CPET parameters to predict shocks and other arrhythmic events in HF patients with ICD, in order to identify a high-risk group for arrhythmias.This was a prospective single-center registry of 61 consecutive patients (mean age 55 +/- 15 years, 18% female), with dilated cardiomyopathy (ischemic etiology in 57%) and ICD, who underwent symptom-limited maximal CPET six months or less before device implantation. Minimum follow-up was 180 days. The primary endpoint was appropriate shock and the composite endpoint was appropriate shock and/or ventricular fibrillation (VF) and/or sustained ventricular tachycardia (VT), which were then correlated with hemodynamic variables (heart rate and blood pressure) and CPET parameters.During a mean follow-up of 27 months, eight patients died (13%), two of them from arrhythmic cause (3.3%), and 16 (26%) patients received at least one appropriate ICD shock, eight (13%) due to VF. Sustained VT was recorded in 23 patients (38%) and nonsustained VT in 42 patients (69%). CPET showed that the group with the primary end point had lower peak VO2, anaerobic threshold and chronotropic reserve. On multivariate analysis, resting heart rate was the only independent predictor of appropriate shock (HR 1.06; 95% CI 1.01-1.10; p = 0.025). Univariate analysis identified peak VO2, anaerobic threshold, VE/VCO2 slope, resting heart rate and heart rate decrease during the first minute of recovery, and systolic blood pressure during exercise as predictive of the composite endpoint (shock/VF/sustained VT). Multivariate analysis identified resting heart rate and peak VO2 as independent predictors, with HR 1.04; 95% CI 1.00-1.09 (p = 0.050) and HR 0.88; 95% CI 0.78-0.98 (p = 0.026), respectively. The best cut-off for resting heart rate to predict the composite and primary endpoints was > 76 bpm (area under the ROC curve: 0.67; 95% CI 0.53-0.78 and 0.65; 95% CI 0.51-0.76, respectively).Resting heart rate and peak VO2 were identified in multivariate analysis as good predictors of arrhythmic events and resting heart rate was the only independent predictor of appropriate shock in HF patients with ICD. Both advanced stage heart failure and sympathetic overdrive may be associated with the development of malignant arrhythmias." @default.
• W170263297 created "2016-06-24" @default.
• W170263297 creator A5001381886 @default.
• W170263297 creator A5004595187 @default.
• W170263297 creator A5009262616 @default.
• W170263297 creator A5013286763 @default.
• W170263297 creator A5013603402 @default.
• W170263297 creator A5025236265 @default.
• W170263297 creator A5034701435 @default.
• W170263297 creator A5038949254 @default.
• W170263297 creator A5041443785 @default.
• W170263297 creator A5052031161 @default.
• W170263297 creator A5060123086 @default.
• W170263297 creator A5074660707 @default.
• W170263297 creator A5078345612 @default.
• W170263297 creator A5088011769 @default.
• W170263297 date "2011-02-01" @default.
• W170263297 modified "2023-09-25" @default.
• W170263297 title "Resting heart rate is a powerful predictor of arrhythmic events in patients with dilated cardiomyopathy and implantable cardioverter-defibrillator." @default.
• W170263297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21553612" @default.
• W170263297 hasPublicationYear "2011" @default.
• W170263297 type Work @default.
• W170263297 sameAs 170263297 @default.
• W170263297 citedByCount "6" @default.
• W170263297 countsByYear W1702632972014 @default.
• W170263297 countsByYear W1702632972015 @default.
• W170263297 countsByYear W1702632972017 @default.
• W170263297 countsByYear W1702632972019 @default.
• W170263297 countsByYear W1702632972023 @default.
• W170263297 crossrefType "journal-article" @default.
• W170263297 hasAuthorship W170263297A5001381886 @default.
• W170263297 hasAuthorship W170263297A5004595187 @default.
• W170263297 hasAuthorship W170263297A5009262616 @default.
• W170263297 hasAuthorship W170263297A5013286763 @default.
• W170263297 hasAuthorship W170263297A5013603402 @default.
• W170263297 hasAuthorship W170263297A5025236265 @default.
• W170263297 hasAuthorship W170263297A5034701435 @default.
• W170263297 hasAuthorship W170263297A5038949254 @default.
• W170263297 hasAuthorship W170263297A5041443785 @default.
• W170263297 hasAuthorship W170263297A5052031161 @default.
• W170263297 hasAuthorship W170263297A5060123086 @default.
• W170263297 hasAuthorship W170263297A5074660707 @default.
• W170263297 hasAuthorship W170263297A5078345612 @default.
• W170263297 hasAuthorship W170263297A5088011769 @default.
• W170263297 hasConcept C126322002 @default.
• W170263297 hasConcept C164705383 @default.
• W170263297 hasConcept C203092338 @default.
• W170263297 hasConcept C2775935837 @default.
• W170263297 hasConcept C2776331378 @default.
• W170263297 hasConcept C2776383484 @default.
• W170263297 hasConcept C2777093960 @default.
• W170263297 hasConcept C2777953023 @default.
• W170263297 hasConcept C2778198053 @default.
• W170263297 hasConcept C2778797674 @default.
• W170263297 hasConcept C2780283014 @default.
• W170263297 hasConcept C2781005686 @default.
• W170263297 hasConcept C2781300812 @default.
• W170263297 hasConcept C535046627 @default.
• W170263297 hasConcept C71924100 @default.
• W170263297 hasConcept C84393581 @default.
• W170263297 hasConceptScore W170263297C126322002 @default.
• W170263297 hasConceptScore W170263297C164705383 @default.
• W170263297 hasConceptScore W170263297C203092338 @default.
• W170263297 hasConceptScore W170263297C2775935837 @default.
• W170263297 hasConceptScore W170263297C2776331378 @default.
• W170263297 hasConceptScore W170263297C2776383484 @default.
• W170263297 hasConceptScore W170263297C2777093960 @default.
• W170263297 hasConceptScore W170263297C2777953023 @default.
• W170263297 hasConceptScore W170263297C2778198053 @default.
• W170263297 hasConceptScore W170263297C2778797674 @default.
• W170263297 hasConceptScore W170263297C2780283014 @default.
• W170263297 hasConceptScore W170263297C2781005686 @default.
• W170263297 hasConceptScore W170263297C2781300812 @default.
• W170263297 hasConceptScore W170263297C535046627 @default.
• W170263297 hasConceptScore W170263297C71924100 @default.
• W170263297 hasConceptScore W170263297C84393581 @default.
• W170263297 hasIssue "2" @default.
• W170263297 hasLocation W1702632971 @default.
• W170263297 hasOpenAccess W170263297 @default.
• W170263297 hasPrimaryLocation W1702632971 @default.
• W170263297 hasRelatedWork W1511973058 @default.
• W170263297 hasRelatedWork W1980865556 @default.
• W170263297 hasRelatedWork W1992079473 @default.
• W170263297 hasRelatedWork W1996582946 @default.
• W170263297 hasRelatedWork W2035824861 @default.
• W170263297 hasRelatedWork W2053841486 @default.
• W170263297 hasRelatedWork W2059645493 @default.
• W170263297 hasRelatedWork W207411552 @default.
• W170263297 hasRelatedWork W2158050586 @default.
• W170263297 hasRelatedWork W2249953144 @default.
• W170263297 hasRelatedWork W2317500344 @default.
• W170263297 hasRelatedWork W2341522284 @default.
• W170263297 hasRelatedWork W2341725702 @default.
• W170263297 hasRelatedWork W2431342553 @default.
• W170263297 hasRelatedWork W2560776182 @default.
• W170263297 hasRelatedWork W2797021361 @default.
• W170263297 hasRelatedWork W2969628747 @default.
• W170263297 hasRelatedWork W2971967272 @default.

• next