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• W17045578 abstract "Drug discovery for neglected tropical diseases is carried out using both target-based and phenotypic approaches. In this paper, target-based approaches are discussed, with a particular focus on human African trypanosomiasis. Target-based drug discovery can be successful, but careful selection of targets is required. There are still very few fully validated drug targets in neglected diseases, and there is a high attrition rate in target-based drug discovery for these diseases. Phenotypic screening is a powerful method in both neglected and non-neglected diseases and has been very successfully used. Identification of molecular targets from phenotypic approaches can be a way to identify potential new drug targets." @default.
• W17045578 created "2016-06-24" @default.
• W17045578 creator A5033358436 @default.
• W17045578 date "2013-09-09" @default.
• W17045578 modified "2023-10-03" @default.
• W17045578 title "Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches" @default.
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• W17045578 doi "https://doi.org/10.1021/jm400362b" @default.
• W17045578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3954685" @default.
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