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- W1704706075 abstract "In 1947, a controlled trial of BCG vaccination was undertaken by the U. S. Public Health Service among 11,262 school children in Muscogee County, Georgia. Participants were first tested with 0.1 µg of PPD; nonreactors to this dose were tested with 2.0 µg of PPD; and nonreactors to the second dose were assigned to control or vaccinee groups. BCG vaccine was given by multiple puncture. Six months later, approximately half of the vaccinees reacted to the first dose of PPD, and more than 90 per cent reacted to the second dose. If indicated, revaccination was done at this time and again three years later. Twenty years after the start of the trial, 47 cases of “definite tuberculosis” had been identified among the study population. The average annual case rate per 100,000 was 156 among first-dose tuberculin reactors; it increased with size of reaction to this dose. Nonreactors to the first dose had an average annual case rate of only 16. Vaccinees had a slightly higher rate than the control group, a difference t..." @default.
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- W1704706075 date "2015-05-14" @default.
- W1704706075 modified "2023-09-26" @default.
- W1704706075 title "Tuberculosis Studies in Muscogee County, Georgia" @default.
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