FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1704713718> ?p ?o ?g. }

• W1704713718 endingPage "20" @default.
• W1704713718 startingPage "404" @default.
• W1704713718 abstract "Two salient features of the pulmonary response to reactive oxidant air pollutants such as ozone are the heterogeneity of response by site within the respiratory tract and the development of tolerance to injury with repeated exposure. The purpose of this study was to establish whether the development of tolerance to long-term exposure is associated with changes in the tracheobronchial epithelium. Male F344-N rats were exposed to 0, 0.12, 0.5, or 1.0 ppm ozone 6 hours/day for 5 days/week for 20 months and killed 1 week post-exposure. Samples for light microscopic morphometry were obtained by microdissection from each infusion-fixed trachea and left lung lobe and included: 1) a cranial bronchus with short path length (generation no. 4 to 5) and small diameter; 2) a central bronchus with short path length (generation no. 4 to 5) and large diameter; and 3) a caudal bronchus with long path length (generation no. 10 to 12) and small diameter. In addition, three sites within the central acinus were examined from cranial, central, and caudal regions. These sites included terminal bronchiole, 0.5 to 1 mm proximal to terminal bronchiole and bronchiolarized alveolar duct. Intraepithelial mucin storage (AB/PAS-positive material quantified by image analysis) within the trachea decreased with dose. Mucin storage was unchanged in the central bronchus, increased threefold with dose in the caudal bronchus, and was six times higher in the cranial bronchus at 1.0 ppm ozone. Epithelial composition was unchanged in trachea or any bronchi; however, we noted a significant dose-dependent increase in nonciliated cell mass and volume fraction in terminal bronchioles in all three regions. There was also a significant increase in nonciliated cell mass in the bronchiolarized alveolar ducts. Bronchiolar nonciliated cells were identified greater than fourfold further into alveolar ducts in 1.0 ppm exposed than in 0 ppm animals. Nonciliated cells occurred almost 200 microns deeper into alveolar ducts in cranial regions than in caudal regions. We conclude: 1) that the development of tolerance to injury produced by long-term exposure to ozone involves changes in airway epithelium and 2) that these changes are site specific and involve alterations in both secretory activity and cellular composition." @default.
• W1704713718 created "2016-06-24" @default.
• W1704713718 creator A5002264876 @default.
• W1704713718 creator A5027437494 @default.
• W1704713718 creator A5045452727 @default.
• W1704713718 creator A5047412918 @default.
• W1704713718 creator A5051502562 @default.
• W1704713718 creator A5073899016 @default.
• W1704713718 date "1994-02-01" @default.
• W1704713718 modified "2023-09-26" @default.
• W1704713718 title "Dose-dependent tolerance to ozone. I. Tracheobronchial epithelial reorganization in rats after 20 months' exposure." @default.
• W1704713718 cites W102115430 @default.
• W1704713718 cites W133445481 @default.
• W1704713718 cites W1482976842 @default.
• W1704713718 cites W1488060180 @default.
• W1704713718 cites W1589707591 @default.
• W1704713718 cites W1961269787 @default.
• W1704713718 cites W1964331251 @default.
• W1704713718 cites W1981276978 @default.
• W1704713718 cites W1983136939 @default.
• W1704713718 cites W1985323809 @default.
• W1704713718 cites W1998839307 @default.
• W1704713718 cites W2024424765 @default.
• W1704713718 cites W2061673926 @default.
• W1704713718 cites W2086475635 @default.
• W1704713718 cites W2161306037 @default.
• W1704713718 cites W2404684281 @default.
• W1704713718 cites W2407424304 @default.
• W1704713718 cites W2410003063 @default.
• W1704713718 cites W2463983807 @default.
• W1704713718 cites W2471237240 @default.
• W1704713718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1887145" @default.
• W1704713718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8311121" @default.
• W1704713718 hasPublicationYear "1994" @default.
• W1704713718 type Work @default.
• W1704713718 sameAs 1704713718 @default.
• W1704713718 citedByCount "18" @default.
• W1704713718 countsByYear W17047137182015 @default.
• W1704713718 crossrefType "journal-article" @default.
• W1704713718 hasAuthorship W1704713718A5002264876 @default.
• W1704713718 hasAuthorship W1704713718A5027437494 @default.
• W1704713718 hasAuthorship W1704713718A5045452727 @default.
• W1704713718 hasAuthorship W1704713718A5047412918 @default.
• W1704713718 hasAuthorship W1704713718A5051502562 @default.
• W1704713718 hasAuthorship W1704713718A5073899016 @default.
• W1704713718 hasConcept C105702510 @default.
• W1704713718 hasConcept C126322002 @default.
• W1704713718 hasConcept C134018914 @default.
• W1704713718 hasConcept C142724271 @default.
• W1704713718 hasConcept C2776178081 @default.
• W1704713718 hasConcept C2777714996 @default.
• W1704713718 hasConcept C2778764654 @default.
• W1704713718 hasConcept C2779644171 @default.
• W1704713718 hasConcept C2780314925 @default.
• W1704713718 hasConcept C2780446580 @default.
• W1704713718 hasConcept C2780957178 @default.
• W1704713718 hasConcept C534529494 @default.
• W1704713718 hasConcept C71924100 @default.
• W1704713718 hasConcept C86803240 @default.
• W1704713718 hasConceptScore W1704713718C105702510 @default.
• W1704713718 hasConceptScore W1704713718C126322002 @default.
• W1704713718 hasConceptScore W1704713718C134018914 @default.
• W1704713718 hasConceptScore W1704713718C142724271 @default.
• W1704713718 hasConceptScore W1704713718C2776178081 @default.
• W1704713718 hasConceptScore W1704713718C2777714996 @default.
• W1704713718 hasConceptScore W1704713718C2778764654 @default.
• W1704713718 hasConceptScore W1704713718C2779644171 @default.
• W1704713718 hasConceptScore W1704713718C2780314925 @default.
• W1704713718 hasConceptScore W1704713718C2780446580 @default.
• W1704713718 hasConceptScore W1704713718C2780957178 @default.
• W1704713718 hasConceptScore W1704713718C534529494 @default.
• W1704713718 hasConceptScore W1704713718C71924100 @default.
• W1704713718 hasConceptScore W1704713718C86803240 @default.
• W1704713718 hasIssue "2" @default.
• W1704713718 hasLocation W17047137181 @default.
• W1704713718 hasOpenAccess W1704713718 @default.
• W1704713718 hasPrimaryLocation W17047137181 @default.
• W1704713718 hasRelatedWork W206105785 @default.
• W1704713718 hasRelatedWork W2089971350 @default.
• W1704713718 hasRelatedWork W2258171784 @default.
• W1704713718 hasRelatedWork W2312685550 @default.
• W1704713718 hasRelatedWork W2362987010 @default.
• W1704713718 hasRelatedWork W2399443411 @default.
• W1704713718 hasRelatedWork W2408286013 @default.
• W1704713718 hasRelatedWork W2460430048 @default.
• W1704713718 hasRelatedWork W3022589611 @default.
• W1704713718 hasRelatedWork W4229450505 @default.
• W1704713718 hasVolume "144" @default.
• W1704713718 isParatext "false" @default.
• W1704713718 isRetracted "false" @default.
• W1704713718 magId "1704713718" @default.
• W1704713718 workType "article" @default.