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• W1706307002 abstract "This chapter discusses the progress of the last few years in our understanding of the architecture of bacterial transcriptional networks (TRNs) and the functions provided by this architecture. The rest of this chapter concerns such local structural analysis, focusing on elementary circuits that make up the network. Other sections of the chapter are devoted to network motifs in the TRN of Escherichia coli, their structure and function, aiming to covey the notion that each motif can carry out specific information processing functions. The analysis of the E. coli TRN revealed four main recurring patterns: (i) autoregulation, (ii) feedforward loop (FFL), (iii) single input module (SIM), and (iv) dense overlapping regulon (DOR). NAR of a TRN linearizes gene response and increases the input dynamic range of its downstream genes. The dynamical functions as well as other properties of the two common FFLs: the coherent type-1 FFL and the incoherent type-1 FFL are discussed. As described in the chapter, different functions are assigned to network motifs based on theory and experiments, with new functions continuously emerging. It is likely that additional studies on other systems in both E. coli, as well as other bacteria, will result in the identification of additional functions of network motifs in isolation and in the context of the entire network. A future challenge is to view network motif behavior within the global dynamics of gene networks, and assign certain functions of the network based on network architecture." @default.
• W1706307002 created "2016-06-24" @default.
• W1706307002 creator A5010209966 @default.
• W1706307002 creator A5038963613 @default.
• W1706307002 date "2014-04-09" @default.
• W1706307002 modified "2023-09-25" @default.
• W1706307002 title "Architecture and Dynamics of Transcriptional Networks" @default.
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