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- W1706803842 abstract "Summary A single intravenous diabetogenic dose of Streptozotocin, 200 mg/kg, produced a 24-hour depression of oxidized and reduced nicotinamide adenine dinucleotide (NAD and NADH) content in mouse liver. This was followed by a gradual return to normal coenzyme concentrations by the end of 48 hours. Intraperitoneal nicotinamide, 500 mg/kg, administered ten minutes prior to Streptozotocin protected animals against NAD depression for approximately 16 hours. Animals receiving nicotinamide alone showed significantly higher liver NAD values than the combination treatment group. It was found that 1-methyl-1-nitrosourea, the nondiabetogenic but antileukemic moiety of the Streptozotocin molecule, could produce a similar dose-related depression of NAD, while Alloxan did not. The serum half-life of Streptozotocin after an intravenous injection, 200 mg/kg, was approximately 5 minutes, with no drug measurable by two hours. Streptozotocin was detectable in the acid-soluble fraction of liver for 20 hours, and it was found that nicotinamide pretreatment did not significantly alter the drug uptake by this organ. Using prevention of diabetes as the criterion of toxicity modification, a schedule of small serial administrations of nicotinamide over a 24-hour period was shown to be more effective than the injection of the total dose just prior to Streptozotocin. It is suggested that Streptozotocin is inhibiting synthesis of pyridine nucleotides." @default.
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- W1706803842 date "1968-08-01" @default.
- W1706803842 modified "2023-09-23" @default.
- W1706803842 title "Streptozotocin: depression of mouse liver pyridine nucleotides." @default.
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