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• W1707029646 abstract "Inhalation of engineered nanoparticles (NP) poses a still unknown risk. Individuals with chronic lung diseases are expected to be more vulnerable to adverse effects of NP than normal subjects, due to altered respiratory structures and functions. Realistic and dose-controlled aerosol exposures were performed using the deposition chamber NACIVT. Well-differentiated normal and cystic fibrosis (CF) human bronchial epithelia (HBE) with established air-liquid interface and the human bronchial epithelial cell line BEAS-2B were exposed to spark-generated silver and carbon nanoaerosols (20 nm diameter) at three different doses. Necrotic and apoptotic cell death, pro-inflammatory response, epithelial function and morphology were assessed within 24 h after aerosol exposure. NP exposure resulted in significantly higher necrosis in CF than normal HBE and BEAS-2B cells. Before and after NP treatment, CF HBE had higher caspase-3 activity and secreted more IL-6 and MCP-1 than normal HBE. Differentiated HBE had higher baseline secretion of IL-8 and less caspase-3 activity and MCP-1 secretion compared to BEAS-2B cells. These biomarkers increased moderately in response to NP exposure, except for MCP-1, which was reduced in HBE after AgNP treatment. No functional and structural alterations of the epithelia were observed in response to NP exposure. Significant differences between cell models suggest that more than one and fully differentiated HBE should be used in future toxicity studies of NP in vitro. Our findings support epidemiologic evidence that subjects with chronic airway diseases are more vulnerable to adverse effects of particulate air pollution. Thus, this sub-population needs to be included in nano-toxicity studies." @default.
• W1707029646 created "2016-06-24" @default.
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• W1707029646 date "2015-05-26" @default.
• W1707029646 modified "2023-10-17" @default.
• W1707029646 title "Acute toxicity of silver and carbon nanoaerosols to normal and cystic fibrosis human bronchial epithelial cells" @default.
• W1707029646 cites W1529565383 @default.
• W1707029646 cites W1925725099 @default.
• W1707029646 cites W1967218717 @default.
• W1707029646 cites W1969775324 @default.
• W1707029646 cites W1969875074 @default.
• W1707029646 cites W1971149849 @default.
• W1707029646 cites W1971377777 @default.
• W1707029646 cites W1973158119 @default.
• W1707029646 cites W1975133586 @default.
• W1707029646 cites W1980556576 @default.
• W1707029646 cites W1992593998 @default.
• W1707029646 cites W1996122273 @default.
• W1707029646 cites W1998195903 @default.
• W1707029646 cites W2008154812 @default.
• W1707029646 cites W2010303079 @default.
• W1707029646 cites W2018979536 @default.
• W1707029646 cites W2020623049 @default.
• W1707029646 cites W2022634662 @default.
• W1707029646 cites W2022647234 @default.
• W1707029646 cites W2022955853 @default.
• W1707029646 cites W2024302469 @default.
• W1707029646 cites W2026879914 @default.
• W1707029646 cites W2028049079 @default.
• W1707029646 cites W2032635216 @default.
• W1707029646 cites W2039599894 @default.
• W1707029646 cites W2043304167 @default.
• W1707029646 cites W2049011151 @default.
• W1707029646 cites W2052588826 @default.
• W1707029646 cites W2054077049 @default.
• W1707029646 cites W2054978971 @default.
• W1707029646 cites W2057496127 @default.
• W1707029646 cites W2058107166 @default.
• W1707029646 cites W2068498370 @default.
• W1707029646 cites W2069497025 @default.
• W1707029646 cites W2073085145 @default.
• W1707029646 cites W2073420921 @default.
• W1707029646 cites W2077776723 @default.
• W1707029646 cites W2078344447 @default.
• W1707029646 cites W2078844404 @default.
• W1707029646 cites W2079477694 @default.
• W1707029646 cites W2082946966 @default.
• W1707029646 cites W2087251636 @default.
• W1707029646 cites W2090005324 @default.
• W1707029646 cites W2090445713 @default.
• W1707029646 cites W2094262202 @default.
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• W1707029646 cites W2101026179 @default.
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• W1707029646 cites W2115377133 @default.
• W1707029646 cites W2116597454 @default.
• W1707029646 cites W2116995925 @default.
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• W1707029646 cites W2130649423 @default.
• W1707029646 cites W2136374404 @default.
• W1707029646 cites W2136570717 @default.
• W1707029646 cites W2136682892 @default.
• W1707029646 cites W2140720810 @default.
• W1707029646 cites W2146983845 @default.
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• W1707029646 cites W2153258032 @default.
• W1707029646 cites W2158899370 @default.
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• W1707029646 cites W2161946971 @default.
• W1707029646 cites W2163577514 @default.
• W1707029646 cites W2168058345 @default.
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• W1707029646 cites W2419098194 @default.
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• W1707029646 doi "https://doi.org/10.3109/17435390.2015.1049233" @default.
• W1707029646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26011645" @default.
• W1707029646 hasPublicationYear "2015" @default.
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