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- W1707076164 abstract "Background: The inflammatory cascade related to water pipe (WP) smoking and airway hyperresponsiveness (AHR) remains unknown. We aimed to determine whether WP smoking is associated with AHR in young WP consumers. Methods: Mannitol challenge test (Aridol® Pharmaxis Ltd) was performed in acute (n=30) and chronic (n=30) WP smokers as well as cigarette smokers (CS, n=30) and life-long non-smokers (n=30). Acute exposition was defined a single episode of WP smoking ≤ 24 hours, chronic as a weekly consumption of WP for ≥ the last 4 weeks. Results: Data of 74 subjects has been analyzed so far (15 acute and 9 chronic WP smokers, 19 CS, 31 non-smokers). Mean age was 22.6±2.4 years, 51.4% male, mean FEV 1 3.76±0.70 (p=ns for all). CS had 5.9±3.2 PY; 35 (47.3%) had a positive allergy test. AHR to mannitol expressed by ≥15% fall in FEV1 was more common in CS (26.3%) as compared to the other groups (p=0.028). The provoking dose to induce a 15% fall in FEV1 (PD15), a measure of sensitivity, was 155mg [115-395] in CS vs 315 mg [155-475] in non-smokers. The response–dose ratio (RDR) (% fall in FEV1/cumulative dose), a measure of reactivity, differed between the groups and was higher in CS 0.023 [0.011–0.051], followed by chronic WP smokers 0.010 [0.007-0.015], acute WP smokers 0.011 [0.006-0.015], and non-smokers 0.007 [0.005-0.017], p=0.031. While RDR differed significantly between CS smokers and non-smokers (p=0.007) and acute WP smokers (p=0.025) it did not between CS and chronic WP smokers (p=0.118). Conclusion: Even modest amounts of cigarette smoking induce AHR to mannitol. Airway reactivity to mannitol is similarly increased in cigarette smokers and chronic water pipe smokers." @default.
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- W1707076164 date "2011-09-01" @default.
- W1707076164 modified "2023-09-22" @default.
- W1707076164 title "Airway reactivity to inhaled mannitol in young water pipe smokers" @default.
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