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- W1707265346 abstract "Granulation is used extensively in the pharmaceutical industry to produce larger granules from fine powdery particles to improve flowability and appearance, reduce dustiness, and to ensure thorough mixing of different ingredients. This last application is a very important unit operation in the pharmaceutical industry to produce non-segregating mixtures of dry powders that would otherwise strongly segregate because of differences in size, shape, density, and surface properties. The so-called “wet” granulation process uses liquids that are dripped, sprayed, or poured into a shearing mass of powder. The granulating fluid is typically composed of water and/or alcohol and may contain surfactants and polymeric binders such as hydroxypropyl cellulose (HPC) or polyvinylpyrrolidone (PVP). The process by which large dry granules are formed from fine powders by using liquid binders is quite complex. An accepted view holds that the liquid solution wets and spreads in the interstices among primary particles, forming liquid bridges that hold them together by capillary and viscous forces. These wet or “green” granules are subsequently dried and the liquid evaporated from the bridges to leave behind solid bridges or “necks” that impart mechanical strength to the dry granule." @default.
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- W1707265346 date "2007-01-01" @default.
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- W1707265346 title "Chapter 26 Morphology and strength development in solid and solidifying interparticle bridges in granules of pharmaceutical powders" @default.
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- W1707265346 doi "https://doi.org/10.1016/s0167-3785(07)80061-3" @default.
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