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- W1707991235 abstract "The genomes of many viruses traffic into the nucleus, where they are either integrated into host chromosomes or maintained as episomal DNA and then transcriptionally activated or silenced. Here, we discuss the existing evidence on how the lentiviruses, adenoviruses, herpesviruses, hepadnaviruses and autonomous parvoviruses enter the nucleus. Depending on the size of the capsid enclosing the genome, three principles of viral nucleic acids import are discussed. The first principle is that the capsid disassembles in the cytosol or in a docked state at the nuclear pore complex and a subviral genomic complex is trafficked through the pore. Second, the genome is injected from a capsid that is docked to the pore complex, and third, import factors are recruited to cytosolic capsids to increase capsid affinity to the pore complex, mediate translocation and allow disassembly in the nucleoplasm." @default.
- W1707991235 created "2016-06-24" @default.
- W1707991235 creator A5056886474 @default.
- W1707991235 creator A5072914179 @default.
- W1707991235 date "2003-03-01" @default.
- W1707991235 modified "2023-10-15" @default.
- W1707991235 title "Nuclear Import of Viral DNA Genomes" @default.
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- W1707991235 doi "https://doi.org/10.1034/j.1600-0854.2003.00114.x" @default.
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