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- W1708230674 endingPage "1824" @default.
- W1708230674 startingPage "1818" @default.
- W1708230674 abstract "The hallmark of the immune system is its ability to produce a seemingly infinite variety pf antigen-binding receptors. This is made possible by molecular and cellular mechanisms uniquely suited to continuously generate a large number of individual receptor molecules and to select some for further expansion. The well-studied genetic rearrangement that results in the juxtaposition of germ line-encoded variable, diversity, and joining elements remains the foundation for diversification on which the repertoire is built. Many of the rules that regulate this phenomenon have been described, although the underlying enzymatic machinery responsible for these events remains to be elucidated. Recent progress in categorizing the immunoglobulin heavy-chain variable region genes into families as well as studies establishing their utilization in both fetal and adult life is helping to further refine these rules. Subsequent cellular interactions 1) permit the discriminant expansion of clones expressing relevant antibody molecules, 2) allow the active affinity alterations needed for effective ongoing immune responses, and 3) limit the potential deleterious effect of autoreactive cells.— Paige, C. J.; Wu, G. E. The B cell repertoire. FASEB J. 1818-1824; 1989." @default.
- W1708230674 created "2016-06-24" @default.
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- W1708230674 date "1989-05-01" @default.
- W1708230674 modified "2023-10-18" @default.
- W1708230674 title "The B cell repertoire" @default.
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- W1708230674 doi "https://doi.org/10.1096/fasebj.3.7.2497040" @default.
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