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- W170845210 abstract "textabstractAdequate levels of thyroid hormone are essential for normal development and growth, sincethyroid hormone plays an important role in virtually all metabolic processes in the humanbody. This is clearly demonstrated in patients with thyroid hormone disorders. Hyperthyroidismleads to high circulating serum thyroid hormone levels. Patients complain of palpitations,excessive sweating, weight loss and can display swelling of thyroid gland, known asgoiter. In contrast, decreased serum thyroid hormone levels due to hypothyroidism canresult in weight gain, depression, atherosclerosis and hypertension.Even subtle changes in serum thyroid parameters in patients with subclinical thyroiddisease can have important consequences on thyroid hormone related end-points, such asatherosclerosis, heart rate, depression and osteoporosis. Therefore, it is likely that smallvariations in genes involved in thyroid hormone metabolism that result in altered thyroidhormone bioactivity can also have effects on clinical end-points. This thesis focuses on theeffect of thyroid hormone pathway genes on serum thyroid hormone levels and clinical endpointsusing a candidate gene approach. In addition, associations between serum thyroidparameters and clinical endpoints, such as osteoporosis and hypertension are studied." @default.
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- W170845210 date "2009-01-14" @default.
- W170845210 modified "2023-09-27" @default.
- W170845210 title "Inter-individual differences in thyroid hormone bioactivity: the effect of genetic variation" @default.
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