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- W1708853785 abstract "The variety of cellular processes controlled by the Rho family proteins, of which Cdc42, Rac, and Rho are the most widely studied members, are mediated through a number of downstream effector proteins, many of which are still being characterized. The members of the Rho subfamily have a far greater number of effector proteins than other G-protein subfamilies. The effectors can be loosely divided into those that bind to Cdc42 and Rac and those that bind to Rho. The effectors are both functionally and structurally diverse, as is the nature of their interactions with the small G proteins. Structurally, the Rho family proteins are distinguished from the Ras family by the presence of an extra pair of helices (the insert region). It has been reported that removal of this insert region in Rac expressed in vivo prevented both the formation of membrane ruffles and transformation. Thus it is expected that at least one target protein of the Rho family will interact with this region. The structures of six Rho family effectors and their complexes have been studied so far and are described here." @default.
- W1708853785 created "2016-06-24" @default.
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- W1708853785 date "2003-01-01" @default.
- W1708853785 modified "2023-10-18" @default.
- W1708853785 title "Structure of Rho Family Targets" @default.
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- W1708853785 doi "https://doi.org/10.1016/b978-012124546-7/50606-9" @default.
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