Matches in SemOpenAlex for { <https://semopenalex.org/work/W1708880448> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1708880448 abstract "Objective: To examine the usefulness of a new behavioral questionnaire for patients with, and at risk for, Huntington’s disease (HD).Background: Behavioral changes, including apathy, depression, irritability, anxiety, disinhibition, difficulty prioritizing and initiating activities, are characteristic features of HD. For families and caregivers, they are often the most distressing aspect of the disease. The assessment of these behavioral disturbances is therefore important.Design/Methods: The Huntington’s Disease-Behavioral Questionnaire (HD-BQ) consists of 30 items with a 3-point rating scale, and takes about 5 minutes to complete. The maximum score is 90, with higher scores indicating more behavioral changes. Reliability, and clinical and construct validity of the HD-BQ were examined using data from 26 HD (mean age, education, CAG=57.5, 15.2 yrs, and 43.3, respectively), 14 preHD (mean age, education, CAG=45.6 yrs, 15.7 yrs, and 41.5), and 10 control subjects (mean age, education=45.4 yrs, 15.3 yrs). Construct validity of the HD-BQ was assessed using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Unified Huntington’s Disease Rating Scale (UHDRS) Total Functional Capacity (TFC) and Total Motor Score (TMS), Problem Behaviors Assessment-Short (PBA-s), Hospital Anxiety and Depression Scale (HADS), and Symptom Checklist-90-Revised (SCL-90) Global Severity Index (GSI).Results: The HD-BQ showed substantial internal consistency (Cronbach α = 0.94). It showed construct validity with high-very high correlations with other behavioral measures (PBA r=0.54; HADS r=0.88; SCL-90 r= 0.85), and poor correlations with measures of cognitive functioning and motor impairment (r=0.01 and 0.10, respectively). No floor or ceiling effects were observed. The HD-BQ discriminated between HD (mean 34.9, range 1-83), preHD (mean 20.7, range 1-54), and control subjects (mean 6.4, range 2-12) (p=0.000).Conclusions: The HD-BQ is a quick, reliable instrument for screening behavioral changes in patients with, and at risk for, HD. Further studies will be needed to confirm and extend these findings.Study supported by: UCSD HDSA CoE and UCSD Shiley-Marcos ADRC NIH P50 AG 005131 Disclosure: Dr. Corey-Bloom has received research support from Janssen Pharmaceutica, Siena, Prana, HSG, and CHDI. Dr. Herndon has nothing to disclose. Ms. Breen9s immediate family holds stock and/or stock options in Wavetec Vision Systems. Dr. Huynh has nothing to disclose. Dr. Gilbert has nothing to disclose." @default.
- W1708880448 created "2016-06-24" @default.
- W1708880448 creator A5003956881 @default.
- W1708880448 creator A5014235238 @default.
- W1708880448 creator A5019629408 @default.
- W1708880448 creator A5021566335 @default.
- W1708880448 creator A5067421197 @default.
- W1708880448 date "2014-04-08" @default.
- W1708880448 modified "2023-10-11" @default.
- W1708880448 title "The Huntington’s Disease-Behavioral Questionnaire (HD-BQ): A New Screening Tool For Behavioral Disturbances In HD (S47.002)" @default.
- W1708880448 hasPublicationYear "2014" @default.
- W1708880448 type Work @default.
- W1708880448 sameAs 1708880448 @default.
- W1708880448 citedByCount "1" @default.
- W1708880448 countsByYear W17088804482015 @default.
- W1708880448 crossrefType "journal-article" @default.
- W1708880448 hasAuthorship W1708880448A5003956881 @default.
- W1708880448 hasAuthorship W1708880448A5014235238 @default.
- W1708880448 hasAuthorship W1708880448A5019629408 @default.
- W1708880448 hasAuthorship W1708880448A5021566335 @default.
- W1708880448 hasAuthorship W1708880448A5067421197 @default.
- W1708880448 hasConcept C106906290 @default.
- W1708880448 hasConcept C118552586 @default.
- W1708880448 hasConcept C126322002 @default.
- W1708880448 hasConcept C129573333 @default.
- W1708880448 hasConcept C138496976 @default.
- W1708880448 hasConcept C139719470 @default.
- W1708880448 hasConcept C15744967 @default.
- W1708880448 hasConcept C162324750 @default.
- W1708880448 hasConcept C169900460 @default.
- W1708880448 hasConcept C171606756 @default.
- W1708880448 hasConcept C1862650 @default.
- W1708880448 hasConcept C2776509080 @default.
- W1708880448 hasConcept C2776599063 @default.
- W1708880448 hasConcept C2776632958 @default.
- W1708880448 hasConcept C2776867660 @default.
- W1708880448 hasConcept C2779134260 @default.
- W1708880448 hasConcept C2780647506 @default.
- W1708880448 hasConcept C2780820931 @default.
- W1708880448 hasConcept C2984915365 @default.
- W1708880448 hasConcept C49453240 @default.
- W1708880448 hasConcept C558461103 @default.
- W1708880448 hasConcept C70410870 @default.
- W1708880448 hasConcept C71924100 @default.
- W1708880448 hasConcept C83849319 @default.
- W1708880448 hasConceptScore W1708880448C106906290 @default.
- W1708880448 hasConceptScore W1708880448C118552586 @default.
- W1708880448 hasConceptScore W1708880448C126322002 @default.
- W1708880448 hasConceptScore W1708880448C129573333 @default.
- W1708880448 hasConceptScore W1708880448C138496976 @default.
- W1708880448 hasConceptScore W1708880448C139719470 @default.
- W1708880448 hasConceptScore W1708880448C15744967 @default.
- W1708880448 hasConceptScore W1708880448C162324750 @default.
- W1708880448 hasConceptScore W1708880448C169900460 @default.
- W1708880448 hasConceptScore W1708880448C171606756 @default.
- W1708880448 hasConceptScore W1708880448C1862650 @default.
- W1708880448 hasConceptScore W1708880448C2776509080 @default.
- W1708880448 hasConceptScore W1708880448C2776599063 @default.
- W1708880448 hasConceptScore W1708880448C2776632958 @default.
- W1708880448 hasConceptScore W1708880448C2776867660 @default.
- W1708880448 hasConceptScore W1708880448C2779134260 @default.
- W1708880448 hasConceptScore W1708880448C2780647506 @default.
- W1708880448 hasConceptScore W1708880448C2780820931 @default.
- W1708880448 hasConceptScore W1708880448C2984915365 @default.
- W1708880448 hasConceptScore W1708880448C49453240 @default.
- W1708880448 hasConceptScore W1708880448C558461103 @default.
- W1708880448 hasConceptScore W1708880448C70410870 @default.
- W1708880448 hasConceptScore W1708880448C71924100 @default.
- W1708880448 hasConceptScore W1708880448C83849319 @default.
- W1708880448 hasLocation W17088804481 @default.
- W1708880448 hasOpenAccess W1708880448 @default.
- W1708880448 hasPrimaryLocation W17088804481 @default.
- W1708880448 hasRelatedWork W1513055284 @default.
- W1708880448 hasRelatedWork W1841717041 @default.
- W1708880448 hasRelatedWork W1966202658 @default.
- W1708880448 hasRelatedWork W1997312621 @default.
- W1708880448 hasRelatedWork W2001248086 @default.
- W1708880448 hasRelatedWork W2016346165 @default.
- W1708880448 hasRelatedWork W2037123984 @default.
- W1708880448 hasRelatedWork W2042787166 @default.
- W1708880448 hasRelatedWork W2051324857 @default.
- W1708880448 hasRelatedWork W2298911185 @default.
- W1708880448 hasRelatedWork W2328834232 @default.
- W1708880448 hasRelatedWork W2564042234 @default.
- W1708880448 hasRelatedWork W2567543884 @default.
- W1708880448 hasRelatedWork W2588968644 @default.
- W1708880448 hasRelatedWork W2754618131 @default.
- W1708880448 hasRelatedWork W2789966887 @default.
- W1708880448 hasRelatedWork W2915252985 @default.
- W1708880448 hasRelatedWork W3028825222 @default.
- W1708880448 hasRelatedWork W3138778966 @default.
- W1708880448 hasRelatedWork W3213369759 @default.
- W1708880448 hasVolume "82" @default.
- W1708880448 isParatext "false" @default.
- W1708880448 isRetracted "false" @default.
- W1708880448 magId "1708880448" @default.
- W1708880448 workType "article" @default.