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• W170922145 abstract "Osteoblasts are cells of mesenchymal origin, which rebuild resorbed bone by synthesizing bone matrix proteins and by inducing bone matrix mineralization. Osteoblasts play a crucial role in creating and mainte- nance of healthy bone architecture, bone repair, and peri-implant bone healing (osseointegration). These bone-forming cells are also involved in regulation of osteoclasts function, and hence bone resorption in osteoclastogenesis process. We have presented our own studies on the subsequent stages of differen- tiation of Human Bone-Derived Cells (HBDCs) that could be a good candidate as an autogenous source for reconstruction and rebuilding of own patient's bone using tissue engineering methods. In this review we discussed the biology of osteoblasts, compared with the HBDCs cultures, under the influence of growth fac- tors (FGF-2, TGF-β, IGF, PDGF) and hormones (PTH, 1,25-dihydroxyvitamin D3, leptin). Our review is also focused on the participation of intercellular adhesion proteins (cadherins, claudins, connexin, 'OsteoMacs'), transcription factors (Cbfa1, Msx-2, Osx, ATF4 ), and others molecules (RANKL, OPG, BMP2, lactofferin, PPARγ) in modulating osteoblasts functions on the basis of current reports, throwing new light on the involvement of osteoblasts during osteogenesis and peri-implant bone healing. Abstract Osteoporosis is often treated with the use of sodium alendronate - a drug that inhibits osteoclast-mediated bone resorption and regulates rate of bone turnover. However the disadvantage of oral administration of sodium alendronate is poor drug absorption from the gastrointestinal track and severe adverse effects. Therefore we propose local sustained drug delivery systems based on poly(lactide-co-glycolide) (PLGA) micro- and nanocarriers, which can be administered directly by simple injections to the required place in the body. In this study we encapsulated sodium alendronate into PLGA micro- and nanospheres via a double-emulsification technique. Emulsion formation in different shear rate conditions was used to optimize the size of the carriers. The prepared microspheres were observed under an inverted optical microscope which confirmed their micrometric size. The nanosphe- res were analyzed by atomic force microscopy, which allowed visualization of their shape and measurement of their size. Moreover the hydrodynamic diameter of the nanospheres, polydispersity index as well as zeta potential were examined by dynamic light scattering. The experiments show that drug release does not depend on the size of the carriers. Analyzed carriers do not cause cytotoxicity upon contact with osteoblast like-cells." @default.
• W170922145 created "2016-06-24" @default.
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• W170922145 date "2013-01-01" @default.
• W170922145 modified "2023-09-27" @default.
• W170922145 title "TISSUE ENGINEERING OF BONE: THE ROLE OF OSTEOBLASTS IN OSTEOGENESIS AND PERI- IMPLANT BONE HEALING" @default.
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