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- W17096249 abstract "Abstract The interpretation of malignancy is linked to that of normal cellular self-renewal. I conjecture that most normal lymphocytes and hemopoietic cells which are not terminally differentiated possess a capacity for self-renewal; and that proliferation is controlled by external or feedback signals for differentiation. The balance between these two processes within a single clone is defined in terms of a number of ordinary nonlinear differential equations. When competition among cells within a clone or among different clones is superimposed, several systemic modes emerge which are used to interpret and describe basic characteristics of the hemopoietic and immune systems. The apparent breakdown of normal regulation in malignancy is proposed to occur at the multi-cellular level. Leukemia, in particular, is seen as a quantitative change in the responsiveness of individual cells to external control, which can lead to substantial alteration of their collective growth pattern as a population. Some of the conceptual and mathematical avenues which this approach opens are discussed." @default.
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- W17096249 date "1984-01-01" @default.
- W17096249 modified "2023-10-14" @default.
- W17096249 title "BALANCE OF GROWTH: CELL-POPULATION APPROACH TO IMMUNITY, HEMOPOIESIS AND CANCER." @default.
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- W17096249 doi "https://doi.org/10.1016/b978-0-08-030156-3.50171-5" @default.
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