FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1710200627> ?p ?o ?g. }

• W1710200627 endingPage "8" @default.
• W1710200627 startingPage "2362" @default.
• W1710200627 abstract "Chromosome 3p is deleted frequently in various types of human cancers, including lung cancer. Recently, the RASSF1A gene was isolated from the 3p21.3 region homozygously deleted in lung and breast cancer cell lines, and it was shown to be inactivated by hypermethylation of the promoter region in lung cancers. In this study, we investigated the pathogenetic and clinicopathological significances of RASSF1A methylation in the development and/or progression of lung adenocarcinoma.Association of RASSF1A methylation with clinicopathological features, allelic imbalance at 3p21.3, p53 mutations, and K-ras mutations was examined in 110 stage I lung adenocarcinomas.Thirty-five of 110 (32%) tumors showed RASSF1A methylation. RASSF1A methylation was dominantly detected in tumors with vascular invasion (P = 0.0242) or pleural involvement (P = 0.0305), and was observed more frequently in poorly differentiated tumors than in well (P = 0.0005) or moderately (P = 0.0835) differentiated tumors. Furthermore, RASSF1A methylation correlated with adverse survival by univariate analysis (P = 0.0368; log-rank test) as well as multivariate analysis (P = 0.032,; risk ratio 2.357; 95% confidence interval, 1.075-5.169). The correlation between RASSF1A methylation and allelic imbalance at 3p21.3 was significant (P = 0.0005), whereas the correlation between RASSF1A methylation and p53 mutation was borderline (P = 0.0842). However, there was no correlation or inverse correlation between RASSF1A methylation and K-ras mutation (P = 0.2193).These results indicated that epigenetic inactivation of RASSF1A plays an important role in the progression of lung adenocarcinoma, and that RASSF1A hypermethylation appears to be a useful molecular marker for the prognosis of patients with stage I lung adenocarcinoma." @default.
• W1710200627 created "2016-06-24" @default.
• W1710200627 creator A5023175666 @default.
• W1710200627 creator A5025520229 @default.
• W1710200627 creator A5043121048 @default.
• W1710200627 creator A5048865240 @default.
• W1710200627 creator A5049388697 @default.
• W1710200627 creator A5060156953 @default.
• W1710200627 creator A5065536577 @default.
• W1710200627 creator A5071696225 @default.
• W1710200627 creator A5082574872 @default.
• W1710200627 creator A5084124315 @default.
• W1710200627 creator A5085632957 @default.
• W1710200627 creator A5086514831 @default.
• W1710200627 date "2002-07-01" @default.
• W1710200627 modified "2023-10-16" @default.
• W1710200627 title "Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma." @default.
• W1710200627 cites W1504197144 @default.
• W1710200627 cites W1556996865 @default.
• W1710200627 cites W1568388409 @default.
• W1710200627 cites W1572023108 @default.
• W1710200627 cites W1598690774 @default.
• W1710200627 cites W1609687385 @default.
• W1710200627 cites W1892327752 @default.
• W1710200627 cites W1893240592 @default.
• W1710200627 cites W1969229561 @default.
• W1710200627 cites W1978620346 @default.
• W1710200627 cites W1988698986 @default.
• W1710200627 cites W1994465394 @default.
• W1710200627 cites W2014294294 @default.
• W1710200627 cites W2047200784 @default.
• W1710200627 cites W2052333525 @default.
• W1710200627 cites W2078979652 @default.
• W1710200627 cites W2081709843 @default.
• W1710200627 cites W2085226130 @default.
• W1710200627 cites W2088706525 @default.
• W1710200627 cites W2092641158 @default.
• W1710200627 cites W2100442886 @default.
• W1710200627 cites W2103067815 @default.
• W1710200627 cites W2113459016 @default.
• W1710200627 cites W2118586965 @default.
• W1710200627 cites W2121153361 @default.
• W1710200627 cites W2137583207 @default.
• W1710200627 cites W2145252755 @default.
• W1710200627 cites W2153354021 @default.
• W1710200627 cites W2165445451 @default.
• W1710200627 cites W2166208988 @default.
• W1710200627 cites W2334576825 @default.
• W1710200627 cites W2000492963 @default.
• W1710200627 cites W2277985727 @default.
• W1710200627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12114441" @default.
• W1710200627 hasPublicationYear "2002" @default.
• W1710200627 type Work @default.
• W1710200627 sameAs 1710200627 @default.
• W1710200627 citedByCount "37" @default.
• W1710200627 countsByYear W17102006272012 @default.
• W1710200627 countsByYear W17102006272013 @default.
• W1710200627 countsByYear W17102006272014 @default.
• W1710200627 countsByYear W17102006272015 @default.
• W1710200627 countsByYear W17102006272018 @default.
• W1710200627 countsByYear W17102006272020 @default.
• W1710200627 crossrefType "journal-article" @default.
• W1710200627 hasAuthorship W1710200627A5023175666 @default.
• W1710200627 hasAuthorship W1710200627A5025520229 @default.
• W1710200627 hasAuthorship W1710200627A5043121048 @default.
• W1710200627 hasAuthorship W1710200627A5048865240 @default.
• W1710200627 hasAuthorship W1710200627A5049388697 @default.
• W1710200627 hasAuthorship W1710200627A5060156953 @default.
• W1710200627 hasAuthorship W1710200627A5065536577 @default.
• W1710200627 hasAuthorship W1710200627A5071696225 @default.
• W1710200627 hasAuthorship W1710200627A5082574872 @default.
• W1710200627 hasAuthorship W1710200627A5084124315 @default.
• W1710200627 hasAuthorship W1710200627A5085632957 @default.
• W1710200627 hasAuthorship W1710200627A5086514831 @default.
• W1710200627 hasConcept C104317684 @default.
• W1710200627 hasConcept C121608353 @default.
• W1710200627 hasConcept C126322002 @default.
• W1710200627 hasConcept C142724271 @default.
• W1710200627 hasConcept C146357865 @default.
• W1710200627 hasConcept C150194340 @default.
• W1710200627 hasConcept C151730666 @default.
• W1710200627 hasConcept C190727270 @default.
• W1710200627 hasConcept C2776256026 @default.
• W1710200627 hasConcept C2777714996 @default.
• W1710200627 hasConcept C2778264664 @default.
• W1710200627 hasConcept C2781182431 @default.
• W1710200627 hasConcept C33288867 @default.
• W1710200627 hasConcept C41091548 @default.
• W1710200627 hasConcept C502942594 @default.
• W1710200627 hasConcept C54355233 @default.
• W1710200627 hasConcept C555283112 @default.
• W1710200627 hasConcept C71924100 @default.
• W1710200627 hasConcept C86803240 @default.
• W1710200627 hasConceptScore W1710200627C104317684 @default.
• W1710200627 hasConceptScore W1710200627C121608353 @default.
• W1710200627 hasConceptScore W1710200627C126322002 @default.
• W1710200627 hasConceptScore W1710200627C142724271 @default.
• W1710200627 hasConceptScore W1710200627C146357865 @default.

• next