FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1710249626> ?p ?o ?g. }

• W1710249626 endingPage "3145" @default.
• W1710249626 startingPage "3138" @default.
• W1710249626 abstract "The ability of mucosally delivered plasmid DNA encoding glycoprotein B (gB) of herpes simplex virus type 1 (HSV-1) to generate systemic as well as distal mucosal immunity was evaluated. BALB/c mice were immunized intranasally (i.n.) with gB DNA or DNA expressing beta-galactosidase (beta-Gal). Two days following immunization, gB and beta-Gal gene expression was detected by reverse transcription (RT)-PCR in lungs and cervical lymph nodes (CLN). Histological analysis showed that beta-Gal protein was expressed in vivo in the lungs and the CLN of animals immunized with i.n. administered beta-Gal DNA. The immune responses generated by i.n. administration of gB DNA with or without cholera toxin (CT) were compared to those generated by intramuscular (i.m.) gB DNA and i.n. live HSV administration. Three i.n. doses of gB DNA over a 3-week period resulted in a distal mucosal immunoglobulin A (IgA) response. In addition, the mucosal IgA response was enhanced by coadministration of CT with gB DNA. The i.m. route of immunization induced a strong IgG response in the serum and vagina but was inefficient in generating a mucosal IgA response. Antigen-specific cytokine ELISPOT analyses as well as the serum IgG1/IgG2a ratio indicated induction of stronger Th2 responses following the additional i.n. administration of CT compared to i.n. or i.m. gB DNA or i.n. live HSV immunization. In addition, mucosal immunization with gB DNA induced anti-HSV cell-mediated immunity in vivo as measured by delayed-type hypersensitivity. Although i.n. DNA immunization was an effective means of inducing mucosal antibody, it was inferior to i.m. DNA delivery in providing protection against lethal HSV challenge via the vaginal route. In addition, both i.m. and i.n. plasmid immunizations failed to generate an immune barrier to viral invasion of the mucosa." @default.
• W1710249626 created "2016-06-24" @default.
• W1710249626 creator A5013287504 @default.
• W1710249626 creator A5031860381 @default.
• W1710249626 creator A5039408547 @default.
• W1710249626 creator A5056818325 @default.
• W1710249626 creator A5090853255 @default.
• W1710249626 date "1997-04-01" @default.
• W1710249626 modified "2023-09-23" @default.
• W1710249626 title "Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization" @default.
• W1710249626 cites W1486323853 @default.
• W1710249626 cites W1527043063 @default.
• W1710249626 cites W1577158615 @default.
• W1710249626 cites W1596798793 @default.
• W1710249626 cites W1980969709 @default.
• W1710249626 cites W1989996096 @default.
• W1710249626 cites W2002022916 @default.
• W1710249626 cites W2008238441 @default.
• W1710249626 cites W2017873272 @default.
• W1710249626 cites W2039742651 @default.
• W1710249626 cites W2049326908 @default.
• W1710249626 cites W2057040665 @default.
• W1710249626 cites W2084742882 @default.
• W1710249626 cites W2087683936 @default.
• W1710249626 cites W2098681375 @default.
• W1710249626 cites W2103423829 @default.
• W1710249626 cites W2108192438 @default.
• W1710249626 cites W2131027478 @default.
• W1710249626 cites W2139205809 @default.
• W1710249626 cites W2157746371 @default.
• W1710249626 cites W2160683088 @default.
• W1710249626 cites W2167525855 @default.
• W1710249626 cites W2167958790 @default.
• W1710249626 cites W2292337439 @default.
• W1710249626 cites W4247041678 @default.
• W1710249626 doi "https://doi.org/10.1128/jvi.71.4.3138-3145.1997" @default.
• W1710249626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/191446" @default.
• W1710249626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9060677" @default.
• W1710249626 hasPublicationYear "1997" @default.
• W1710249626 type Work @default.
• W1710249626 sameAs 1710249626 @default.
• W1710249626 citedByCount "209" @default.
• W1710249626 countsByYear W17102496262012 @default.
• W1710249626 countsByYear W17102496262013 @default.
• W1710249626 countsByYear W17102496262014 @default.
• W1710249626 countsByYear W17102496262015 @default.
• W1710249626 countsByYear W17102496262016 @default.
• W1710249626 countsByYear W17102496262018 @default.
• W1710249626 countsByYear W17102496262021 @default.
• W1710249626 countsByYear W17102496262023 @default.
• W1710249626 crossrefType "journal-article" @default.
• W1710249626 hasAuthorship W1710249626A5013287504 @default.
• W1710249626 hasAuthorship W1710249626A5031860381 @default.
• W1710249626 hasAuthorship W1710249626A5039408547 @default.
• W1710249626 hasAuthorship W1710249626A5056818325 @default.
• W1710249626 hasAuthorship W1710249626A5090853255 @default.
• W1710249626 hasBestOaLocation W17102496261 @default.
• W1710249626 hasConcept C153911025 @default.
• W1710249626 hasConcept C159047783 @default.
• W1710249626 hasConcept C159654299 @default.
• W1710249626 hasConcept C167508917 @default.
• W1710249626 hasConcept C195856716 @default.
• W1710249626 hasConcept C203014093 @default.
• W1710249626 hasConcept C22744801 @default.
• W1710249626 hasConcept C2522874641 @default.
• W1710249626 hasConcept C2776090121 @default.
• W1710249626 hasConcept C2779053233 @default.
• W1710249626 hasConcept C2779341262 @default.
• W1710249626 hasConcept C2780801004 @default.
• W1710249626 hasConcept C2780868878 @default.
• W1710249626 hasConcept C2781196997 @default.
• W1710249626 hasConcept C54355233 @default.
• W1710249626 hasConcept C552990157 @default.
• W1710249626 hasConcept C86803240 @default.
• W1710249626 hasConcept C8891405 @default.
• W1710249626 hasConceptScore W1710249626C153911025 @default.
• W1710249626 hasConceptScore W1710249626C159047783 @default.
• W1710249626 hasConceptScore W1710249626C159654299 @default.
• W1710249626 hasConceptScore W1710249626C167508917 @default.
• W1710249626 hasConceptScore W1710249626C195856716 @default.
• W1710249626 hasConceptScore W1710249626C203014093 @default.
• W1710249626 hasConceptScore W1710249626C22744801 @default.
• W1710249626 hasConceptScore W1710249626C2522874641 @default.
• W1710249626 hasConceptScore W1710249626C2776090121 @default.
• W1710249626 hasConceptScore W1710249626C2779053233 @default.
• W1710249626 hasConceptScore W1710249626C2779341262 @default.
• W1710249626 hasConceptScore W1710249626C2780801004 @default.
• W1710249626 hasConceptScore W1710249626C2780868878 @default.
• W1710249626 hasConceptScore W1710249626C2781196997 @default.
• W1710249626 hasConceptScore W1710249626C54355233 @default.
• W1710249626 hasConceptScore W1710249626C552990157 @default.
• W1710249626 hasConceptScore W1710249626C86803240 @default.
• W1710249626 hasConceptScore W1710249626C8891405 @default.
• W1710249626 hasIssue "4" @default.
• W1710249626 hasLocation W17102496261 @default.
• W1710249626 hasLocation W17102496262 @default.
• W1710249626 hasLocation W17102496263 @default.
• W1710249626 hasLocation W17102496264 @default.

• next