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- W1710343418 startingPage "1897" @default.
- W1710343418 abstract "Direct microcalorimetric measurements allow determination of both the δH and association constant of biological complexes ifK a value does not exceed 106 M −1. For higherK a values, δH can obviously be determined; this paper describes an original microcalorimetric method that permits determination of such high association constants. This method is based on the analysis of the competitive effect between two ligands having the same binding site in their receptor. As an example, the affinity constant for thymidylate synthase of a novel antifolate, CB 3717. was found to be 1.4 · 107 M −1 using methotrexate polyglutamate MTX-G2 (K a=2.3·105 M −1) as competitor." @default.
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- W1710343418 date "1991-08-01" @default.
- W1710343418 modified "2023-10-16" @default.
- W1710343418 title "Microcalorimetric study of the binding of methotrexate and its metabolites to thymidylate synthase" @default.
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- W1710343418 doi "https://doi.org/10.1007/bf01912220" @default.
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