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- W1710360154 abstract "Background and Goal of Study: Atropine is a competitive antagonist of cholinergic receptors and is widely used to blunt the increased vagal tone that is often caused by surgical manipulations. It increases heart rate(HR) with minimal effects on mean arterial pressure(MAP) and cardiac output(CO). Norepinephrine(NOR) is a catecholamine used to increase MAP and CO in several medical conditions. Its effect is based on the positive inotropic and chronotropic effects via cardiac β1 receptors and at higher doses on vasoconstriction via vascular α receptors. There are currently no studies revealing the pharmacological interaction of these drugs in patients under total intravenous anesthesia. We therefore studied the effects of atropine on HR, MAP and CO of atropine in combination with (NOR+) or without low-dose NOR (NOR-). Materials and Methods: After local EC approval and written informed consent, 23 patients scheduled for ophthalmic surgery under general anaesthesia were included. If the MAP decreased < 80% of baseline value, NOR 0.05 µg/ kg/min was started. If the HR was < 60bpm when vagal stimulation was imminent, atropine 0.5mg was administered(all patients). HR, MAP and CO were recorded noninvasively(Nexfin, BMEye, Amsterdam). All recordings were synchronised at the moment of atropine administration and analysed in two groups (with or without NOR). Results and Discussion: Changes in HR, MAP and CO were larger in the NOR+ group (14 patients) than in the NOR-group (9 patients). At 300 seconds, the mean(SD) HR increased 32(18) vs 19(11) bpm from baseline. The MAP increased 24(11) vs 5(8) mmHg. The CO increased 3(1.9) versus 0.7(0.8) L/min. All differences were significant (p< 0.05) Conclusions: The haemodynamic effects of atropine are more prominent in the presence of NOR. This study reveals that atropine exerts more advantageous hemodynamic effects in the presence of low-dose NOR." @default.
- W1710360154 created "2016-06-24" @default.
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- W1710360154 date "2013-03-07" @default.
- W1710360154 modified "2023-09-27" @default.
- W1710360154 title "Atropine increases the positive adrenergic effects of norepinephrine: a pilot study" @default.
- W1710360154 doi "https://doi.org/10.7490/f1000research.1092948.1" @default.
- W1710360154 hasPublicationYear "2013" @default.
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