Matches in SemOpenAlex for { <https://semopenalex.org/work/W1710437513> ?p ?o ?g. }
- W1710437513 endingPage "720" @default.
- W1710437513 startingPage "712" @default.
- W1710437513 abstract "The results of recent studies have implicated local inflammation and complement activation as the processes involved in the pathogenesis of age-related macular degeneration (AMD). We have demonstrated that amyloid beta (Abeta), which is deposited in drusen, causes an imbalance in the angiogenesis-related factors in retinal pigment epithelial cells. We have also shown that neprilysin gene-disrupted mice accumulate Abeta, and develop several features of AMD. The purpose of this study was to investigate the mechanisms involved in the development of AMD that are triggered by Abeta. Our results showed that Abeta binds to complement factor I which inhibits the ability of factor I to cleave C3b to inactivated iC3b. Factor H and factor I are soluble complement-activation inhibitors, and preincubation of factor I with Abeta in the presence of factor H abolished the ability of Abeta to cleave C3b, and also abolished the ability of factor I to cleave FGR-AMC. In contrast, Abeta did not affect the function of factor H even after binding. The production of iC3b was significantly decreased when C3b and factor H were incubated with the eyes from neprilysin gene-disrupted mice as compared with when C3b and factor H were incubated with eyes from age-matched wild-type mice. These results suggest that Abeta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues. These findings link four factors that have been suggested to be associated with AMD: inflammation, complement activation, Abeta deposition, and drusen." @default.
- W1710437513 created "2016-06-24" @default.
- W1710437513 creator A5021359937 @default.
- W1710437513 creator A5023317571 @default.
- W1710437513 creator A5026189087 @default.
- W1710437513 creator A5029122307 @default.
- W1710437513 creator A5032660436 @default.
- W1710437513 creator A5034487242 @default.
- W1710437513 creator A5043555116 @default.
- W1710437513 creator A5054666711 @default.
- W1710437513 creator A5074551476 @default.
- W1710437513 creator A5088702685 @default.
- W1710437513 creator A5091908663 @default.
- W1710437513 date "2008-07-01" @default.
- W1710437513 modified "2023-10-12" @default.
- W1710437513 title "Altered Function of Factor I Caused by Amyloid β: Implication for Pathogenesis of Age-Related Macular Degeneration from Drusen" @default.
- W1710437513 cites W1555208677 @default.
- W1710437513 cites W1585939626 @default.
- W1710437513 cites W1595972774 @default.
- W1710437513 cites W1857401373 @default.
- W1710437513 cites W1883306593 @default.
- W1710437513 cites W1910602244 @default.
- W1710437513 cites W1965395547 @default.
- W1710437513 cites W1966374553 @default.
- W1710437513 cites W1967176607 @default.
- W1710437513 cites W1971882192 @default.
- W1710437513 cites W1974997884 @default.
- W1710437513 cites W1977327764 @default.
- W1710437513 cites W1980825524 @default.
- W1710437513 cites W1984481064 @default.
- W1710437513 cites W1984944701 @default.
- W1710437513 cites W1997288094 @default.
- W1710437513 cites W2000399151 @default.
- W1710437513 cites W2003101845 @default.
- W1710437513 cites W2008189019 @default.
- W1710437513 cites W2009256817 @default.
- W1710437513 cites W2027707278 @default.
- W1710437513 cites W2031091916 @default.
- W1710437513 cites W2036097456 @default.
- W1710437513 cites W2056617843 @default.
- W1710437513 cites W2064595835 @default.
- W1710437513 cites W2075021230 @default.
- W1710437513 cites W2075829521 @default.
- W1710437513 cites W2083280149 @default.
- W1710437513 cites W2094275695 @default.
- W1710437513 cites W2105123991 @default.
- W1710437513 cites W2105479207 @default.
- W1710437513 cites W2105507716 @default.
- W1710437513 cites W2106901733 @default.
- W1710437513 cites W2108676263 @default.
- W1710437513 cites W2113784410 @default.
- W1710437513 cites W2116784956 @default.
- W1710437513 cites W2117386992 @default.
- W1710437513 cites W2120704640 @default.
- W1710437513 cites W2122106651 @default.
- W1710437513 cites W2125236492 @default.
- W1710437513 cites W2129010323 @default.
- W1710437513 cites W2133019124 @default.
- W1710437513 cites W2136496671 @default.
- W1710437513 cites W2136501493 @default.
- W1710437513 cites W2149709370 @default.
- W1710437513 cites W2160429819 @default.
- W1710437513 cites W2164887773 @default.
- W1710437513 cites W2325814183 @default.
- W1710437513 cites W3145351529 @default.
- W1710437513 cites W4238550599 @default.
- W1710437513 cites W92737290 @default.
- W1710437513 doi "https://doi.org/10.4049/jimmunol.181.1.712" @default.
- W1710437513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18566438" @default.
- W1710437513 hasPublicationYear "2008" @default.
- W1710437513 type Work @default.
- W1710437513 sameAs 1710437513 @default.
- W1710437513 citedByCount "70" @default.
- W1710437513 countsByYear W17104375132012 @default.
- W1710437513 countsByYear W17104375132013 @default.
- W1710437513 countsByYear W17104375132014 @default.
- W1710437513 countsByYear W17104375132015 @default.
- W1710437513 countsByYear W17104375132016 @default.
- W1710437513 countsByYear W17104375132017 @default.
- W1710437513 countsByYear W17104375132018 @default.
- W1710437513 countsByYear W17104375132020 @default.
- W1710437513 countsByYear W17104375132021 @default.
- W1710437513 countsByYear W17104375132022 @default.
- W1710437513 countsByYear W17104375132023 @default.
- W1710437513 crossrefType "journal-article" @default.
- W1710437513 hasAuthorship W1710437513A5021359937 @default.
- W1710437513 hasAuthorship W1710437513A5023317571 @default.
- W1710437513 hasAuthorship W1710437513A5026189087 @default.
- W1710437513 hasAuthorship W1710437513A5029122307 @default.
- W1710437513 hasAuthorship W1710437513A5032660436 @default.
- W1710437513 hasAuthorship W1710437513A5034487242 @default.
- W1710437513 hasAuthorship W1710437513A5043555116 @default.
- W1710437513 hasAuthorship W1710437513A5054666711 @default.
- W1710437513 hasAuthorship W1710437513A5074551476 @default.
- W1710437513 hasAuthorship W1710437513A5088702685 @default.
- W1710437513 hasAuthorship W1710437513A5091908663 @default.
- W1710437513 hasBestOaLocation W17104375131 @default.
- W1710437513 hasConcept C111684460 @default.