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• W1710793119 endingPage "4433" @default.
• W1710793119 startingPage "4427" @default.
• W1710793119 abstract "Although information about the genetic basis and mechanisms of Shigella flexneri cellular invasion is accumulating, little is known about changes in cell signaling and their consequences following bacterium-host cell interactions. A general result of signal transduction is alterations in the levels and/or activities of transcription factors. Alterations in transcription factor binding activities were observed following challenge with S. flexneri. Changes in the DNA-binding activities of cellular transcription factors to AP1, AP2, cyclic AMP response element, CTF1/NF1, NF-kappa B/Rel, OCT1, and SP1 DNA-binding sites were investigated by electrophoretic mobility shift assays. NF-kappa B/Rel DNA-binding activity was enhanced more than 11-fold by cellular invasion; noninvasive S. flexneri strains induced low levels of kappa B DNA binding. Both subunits of the NF-kappa B transcription factor, p50 and p65, but not c-Rel (p85), are components of the kappa B DNA-binding activity. These data suggest that changes in cellular transcription factor binding activity are a consequence of S. flexneri invasion, and these changes could play a role in the initial host response or in the pathogenesis of the disease." @default.
• W1710793119 created "2016-06-24" @default.
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• W1710793119 date "1993-10-01" @default.
• W1710793119 modified "2023-09-27" @default.
• W1710793119 title "Shigella flexneri invasion of HeLa cells induces NF-kappa B DNA-binding activity" @default.
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• W1710793119 doi "https://doi.org/10.1128/iai.61.10.4427-4433.1993" @default.
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