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• W1710874988 abstract "POD-1/ TCF21 may play a crucial role in adrenal and gonadal homeostasis and represses Sf-1 /SF-1 expression in adrenocortical tumor cells. SF-1 and LRH-1 are members of the Fzt-F1 subfamily of nuclear receptors. LRH-1 is involved in several biological processes, and both LRH-1 and its repressor SHP are involved in many types of cancer. In order to assess whether POD-1 can regulate LRH-1 via the same mechanism that regulates SF-1, we analyzed the endogenous mRNA levels of POD-1 , SHP , and LRH-1 in hepatocarcinoma and adrenocortical tumor cells using qRT-PCR. Hereafter, these tumor cells were transiently transfected with pCMVMycPod-1, and the effect of POD-1 overexpression on E-box elements in the LRH-1 and SHP promoter region were analyzed by ChIP assay. Also, Cyclin E1 protein expression was analyzed to detect cell cycle progression. We found that POD-1 overexpression significantly decreased SHP /SHP mRNA and protein levels through POD-1 binding to the E-box sequence in the SHP promoter. Decreased SHP expression affected LRH-1 regulation and increased Cyclin E1. These findings show that POD-1/ TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis, which could lead to the discovery of relevant biomarkers." @default.
• W1710874988 created "2016-06-24" @default.
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• W1710874988 date "2015-01-01" @default.
• W1710874988 modified "2023-10-12" @default.
• W1710874988 title "POD-1/<i>TCF21</i>Reduces SHP Expression, Affecting<i>LRH-1</i>Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma Tumor Cells" @default.
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• W1710874988 doi "https://doi.org/10.1155/2015/841784" @default.
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