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- W1711013043 endingPage "2023" @default.
- W1711013043 startingPage "2015" @default.
- W1711013043 abstract "Abstract Our recent studies suggest that human squamous cell carcinoma of the head and neck (SCCHN) is capable of activating an intrinsic mechanism of programmed-cell death in interacting lymphocytes in situ and in vitro. The current study used Jurkat T-cell line as a model to investigate intracellular apoptotic events in T cells interacting with SCCHN. Apoptosis induced in T lymphocytes by tumor cells was in part Fas-mediated, since it was partially, but significantly, inhibited in the presence of anti-Fas ligand Ab or in Fas-resistant Jurkat cells. The synthetic caspase inhibitors, N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) and N-benzyloxycarbonyl-Asp-glu-Val-Asp-fluoromethyl ketone (Z-DEVD-FMK), effectively blocked apoptosis of Jurkat cells co-incubated with SCCHN cell lines, suggesting the involvement of caspases in tumor-induced apoptosis of lymphocytes. Overexpression of CrmA, an inhibitor of caspase-1 and caspase-8, partially inhibited tumor-induced T-cell death. Caspase-8 and caspase-3 were identified as effector molecules in the execution of tumor-induced T-cell death, since the proform enzymes were processed into active subunits during co-incubation of T cells with tumor cells. Furthermore, co-incubation with tumor cells resulted in cleavage of poly(ADP-ribose) polymerase (PARP), a common caspase-3 substrate, and in cleavage of TcR-ζ chain, shown by us to be a T-cell specific caspase-3 substrate. Overexpression of Bcl-2 did not provide protection of T cells from SCCHN-induced DNA degradation. Instead, the Bcl-2 protein was cleaved in the target T cells during their co-incubation with tumor cells. These findings demonstrate that tumor cells can trigger in T lymphocytes caspase-dependent apoptotic cascades, which are not effectively protected by Bcl-2." @default.
- W1711013043 created "2016-06-24" @default.
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- W1711013043 date "2000-03-15" @default.
- W1711013043 modified "2023-10-03" @default.
- W1711013043 title "Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events" @default.
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- W1711013043 cites W1621124914 @default.
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- W1711013043 cites W1667164869 @default.
- W1711013043 cites W1915589840 @default.
- W1711013043 cites W1942214720 @default.
- W1711013043 cites W1968599399 @default.
- W1711013043 cites W1973109581 @default.
- W1711013043 cites W1979444649 @default.
- W1711013043 cites W1979842763 @default.
- W1711013043 cites W1982661150 @default.
- W1711013043 cites W1984049955 @default.
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- W1711013043 cites W1992637685 @default.
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- W1711013043 cites W2007332721 @default.
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- W1711013043 cites W2036265336 @default.
- W1711013043 cites W2036937264 @default.
- W1711013043 cites W2043651078 @default.
- W1711013043 cites W2044117808 @default.
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- W1711013043 doi "https://doi.org/10.1182/blood.v95.6.2015" @default.
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