Matches in SemOpenAlex for { <https://semopenalex.org/work/W1711156738> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1711156738 endingPage "1052" @default.
- W1711156738 startingPage "1047" @default.
- W1711156738 abstract "In a search for adjuvants of non-bacterial origin for immunization with ganglioside, we investigated whether chemical coupling to immune stimulatory protein could increase the immunogenicity of sialoglycosphingolipid. A novel method for the linkage of glycosphingolipids, including gangliosides, to protein was established. The procedure includes lysis of the sphingoid double bond by ozone, reduction of the ozonolysis product to the aldehyde, and coupling to amino groups, either directly by reductamination, or by conjugation via a long aliphatic chain dicarboxylic acid linker. Using this method, gangliosides Gfptl (IV2-Fuc-, II3NeuAc-Gg4,Cer), Glac2 [II3(NeuAc)2-LacCer], and Gtetl (II3NeuAc-Gg4,Cer) were coupled to keyhole limpet hemocyanin (KLH), and the immunogenicity of the conjugates was tested. Immunization of mice with the KLH-ganglioside conjugates led in each case to the formation of IgG- and IgM antibodies that recognized the underivatized gangliosides, respectively. In contrast to this, mixtures of KLH and ganglioside proved ineffective for immunization. KLH-tumor-associated ganglioside conjugates may, therefore, be considered as possible vaccines in immune therapy of cancer." @default.
- W1711156738 created "2016-06-24" @default.
- W1711156738 creator A5011110513 @default.
- W1711156738 creator A5017744511 @default.
- W1711156738 creator A5023904630 @default.
- W1711156738 creator A5043612440 @default.
- W1711156738 creator A5091448110 @default.
- W1711156738 date "1994-06-01" @default.
- W1711156738 modified "2023-09-27" @default.
- W1711156738 title "Specific Immunization Using Keyhole Limpet Hemocyanin-Ganglioside Conjugates1" @default.
- W1711156738 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a124455" @default.
- W1711156738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7982880" @default.
- W1711156738 hasPublicationYear "1994" @default.
- W1711156738 type Work @default.
- W1711156738 sameAs 1711156738 @default.
- W1711156738 citedByCount "21" @default.
- W1711156738 countsByYear W17111567382012 @default.
- W1711156738 crossrefType "journal-article" @default.
- W1711156738 hasAuthorship W1711156738A5011110513 @default.
- W1711156738 hasAuthorship W1711156738A5017744511 @default.
- W1711156738 hasAuthorship W1711156738A5023904630 @default.
- W1711156738 hasAuthorship W1711156738A5043612440 @default.
- W1711156738 hasAuthorship W1711156738A5091448110 @default.
- W1711156738 hasConcept C134306372 @default.
- W1711156738 hasConcept C159654299 @default.
- W1711156738 hasConcept C185592680 @default.
- W1711156738 hasConcept C197336794 @default.
- W1711156738 hasConcept C203014093 @default.
- W1711156738 hasConcept C2776727803 @default.
- W1711156738 hasConcept C2777331542 @default.
- W1711156738 hasConcept C2777351567 @default.
- W1711156738 hasConcept C2779915011 @default.
- W1711156738 hasConcept C2780801004 @default.
- W1711156738 hasConcept C2780868878 @default.
- W1711156738 hasConcept C33923547 @default.
- W1711156738 hasConcept C55493867 @default.
- W1711156738 hasConcept C86803240 @default.
- W1711156738 hasConcept C8891405 @default.
- W1711156738 hasConceptScore W1711156738C134306372 @default.
- W1711156738 hasConceptScore W1711156738C159654299 @default.
- W1711156738 hasConceptScore W1711156738C185592680 @default.
- W1711156738 hasConceptScore W1711156738C197336794 @default.
- W1711156738 hasConceptScore W1711156738C203014093 @default.
- W1711156738 hasConceptScore W1711156738C2776727803 @default.
- W1711156738 hasConceptScore W1711156738C2777331542 @default.
- W1711156738 hasConceptScore W1711156738C2777351567 @default.
- W1711156738 hasConceptScore W1711156738C2779915011 @default.
- W1711156738 hasConceptScore W1711156738C2780801004 @default.
- W1711156738 hasConceptScore W1711156738C2780868878 @default.
- W1711156738 hasConceptScore W1711156738C33923547 @default.
- W1711156738 hasConceptScore W1711156738C55493867 @default.
- W1711156738 hasConceptScore W1711156738C86803240 @default.
- W1711156738 hasConceptScore W1711156738C8891405 @default.
- W1711156738 hasIssue "6" @default.
- W1711156738 hasLocation W17111567381 @default.
- W1711156738 hasLocation W17111567382 @default.
- W1711156738 hasOpenAccess W1711156738 @default.
- W1711156738 hasPrimaryLocation W17111567381 @default.
- W1711156738 hasRelatedWork W1617229007 @default.
- W1711156738 hasRelatedWork W1711156738 @default.
- W1711156738 hasRelatedWork W1971730706 @default.
- W1711156738 hasRelatedWork W1977647878 @default.
- W1711156738 hasRelatedWork W1978765629 @default.
- W1711156738 hasRelatedWork W2060269837 @default.
- W1711156738 hasRelatedWork W2079720483 @default.
- W1711156738 hasRelatedWork W2235001436 @default.
- W1711156738 hasRelatedWork W2801952436 @default.
- W1711156738 hasRelatedWork W62158587 @default.
- W1711156738 hasVolume "115" @default.
- W1711156738 isParatext "false" @default.
- W1711156738 isRetracted "false" @default.
- W1711156738 magId "1711156738" @default.
- W1711156738 workType "article" @default.