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• W1711501290 abstract "Using nanopores to sequence DNA rapidly and at a low cost has the potential to radically transform the field of genomic research. However, despite all the exciting developments in the field, sequencing DNA using a nanopore has yet to be demonstrated. Among the many problems that hinder development of the nanopore sequencing methods is the inability of current experimental techniques to visualize DNA conformations in a nanopore and directly relate the microscopic state of the system to the measured signal. We have recently shown that such tasks could be accomplished through computation. This chapter provides step-by-step instructions of how to build atomic scale models of biological and solid-state nanopore systems, use the molecular dynamics method to simulate the electric field-driven transport of ions and DNA through the nanopores, and analyze the results of such computational experiments." @default.
• W1711501290 created "2016-06-24" @default.
• W1711501290 creator A5055004933 @default.
• W1711501290 creator A5069981197 @default.
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• W1711501290 date "2011-01-01" @default.
• W1711501290 modified "2023-10-10" @default.
• W1711501290 title "Modeling Nanopores for Sequencing DNA" @default.
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• W1711501290 doi "https://doi.org/10.1007/978-1-61779-142-0_22" @default.
• W1711501290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21674382" @default.
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