Matches in SemOpenAlex for { <https://semopenalex.org/work/W1712202213> ?p ?o ?g. }
- W1712202213 endingPage "983" @default.
- W1712202213 startingPage "970" @default.
- W1712202213 abstract "Summary Chemical modifications of components of the bacterial cell envelope can enhance resistance to antimicrobial agents. Why then are such modifications produced only under specific conditions? Here, we address this question by examining the role of regulated variations in O ‐antigen length in the lipopolysaccharide ( LPS ), a glycolipid that forms most of the outer leaflet of the outer membrane in Gram‐negative bacteria. We determined that activation of the PmrA / PmrB two‐component system, which is the major regulator of LPS alterations in S almonella enterica serovar T yphimurium, impaired growth of S almonella in bile. This growth defect required the PmrA ‐activated gene wzz st , which encodes the protein that determines long O ‐antigen chain length and confers resistance to complement‐mediated killing. By contrast, this growth defect did not require the wzz fepE gene, which controls production of very long O ‐antigen, or other PmrA ‐activated genes that mediate modifications of lipid A or core regions of the LPS . Additionally, we establish that long O ‐antigen inhibits growth in bile only in the presence of enterobacterial common antigen, an outer‐membrane glycolipid that contributes to bile resistance. Our results suggest that S almonella regulates the proportion of long O ‐antigen in its LPS to respond to the different conditions it faces during infection." @default.
- W1712202213 created "2016-06-24" @default.
- W1712202213 creator A5041504450 @default.
- W1712202213 creator A5063545607 @default.
- W1712202213 date "2013-05-05" @default.
- W1712202213 modified "2023-10-03" @default.
- W1712202213 title "Conflicting roles for a cell surface modification in<i>Salmonella</i>" @default.
- W1712202213 cites W1498580352 @default.
- W1712202213 cites W1568314805 @default.
- W1712202213 cites W1575381144 @default.
- W1712202213 cites W1577239482 @default.
- W1712202213 cites W1898098259 @default.
- W1712202213 cites W1966419853 @default.
- W1712202213 cites W1971264244 @default.
- W1712202213 cites W1982760680 @default.
- W1712202213 cites W1992144107 @default.
- W1712202213 cites W1995777663 @default.
- W1712202213 cites W1996901586 @default.
- W1712202213 cites W1997494954 @default.
- W1712202213 cites W1998776122 @default.
- W1712202213 cites W2008407072 @default.
- W1712202213 cites W2009335524 @default.
- W1712202213 cites W2012487674 @default.
- W1712202213 cites W2014361215 @default.
- W1712202213 cites W2014973946 @default.
- W1712202213 cites W2016177577 @default.
- W1712202213 cites W2023511461 @default.
- W1712202213 cites W2028063089 @default.
- W1712202213 cites W2033129684 @default.
- W1712202213 cites W2034541624 @default.
- W1712202213 cites W2035517952 @default.
- W1712202213 cites W2035883197 @default.
- W1712202213 cites W2035973676 @default.
- W1712202213 cites W2036492728 @default.
- W1712202213 cites W2049190887 @default.
- W1712202213 cites W2056618449 @default.
- W1712202213 cites W2057399524 @default.
- W1712202213 cites W2059016980 @default.
- W1712202213 cites W2064697520 @default.
- W1712202213 cites W2072260255 @default.
- W1712202213 cites W2072760270 @default.
- W1712202213 cites W2074936140 @default.
- W1712202213 cites W2078785671 @default.
- W1712202213 cites W2085787795 @default.
- W1712202213 cites W2091813080 @default.
- W1712202213 cites W2093140758 @default.
- W1712202213 cites W2098767902 @default.
- W1712202213 cites W2101363646 @default.
- W1712202213 cites W2101580369 @default.
- W1712202213 cites W2102609496 @default.
- W1712202213 cites W2102906662 @default.
- W1712202213 cites W2104891233 @default.
- W1712202213 cites W2106079980 @default.
- W1712202213 cites W2107870682 @default.
- W1712202213 cites W2110085694 @default.
- W1712202213 cites W2113410040 @default.
- W1712202213 cites W2115494622 @default.
- W1712202213 cites W2115993183 @default.
- W1712202213 cites W2115996594 @default.
- W1712202213 cites W2116137883 @default.
- W1712202213 cites W2118248940 @default.
- W1712202213 cites W2119652586 @default.
- W1712202213 cites W2120061656 @default.
- W1712202213 cites W2121085961 @default.
- W1712202213 cites W2122656843 @default.
- W1712202213 cites W2125165422 @default.
- W1712202213 cites W2125289692 @default.
- W1712202213 cites W2130317337 @default.
- W1712202213 cites W2139360734 @default.
- W1712202213 cites W2141549494 @default.
- W1712202213 cites W2142146745 @default.
- W1712202213 cites W2144541437 @default.
- W1712202213 cites W2150292428 @default.
- W1712202213 cites W2151387894 @default.
- W1712202213 cites W2153245849 @default.
- W1712202213 cites W2157217625 @default.
- W1712202213 cites W2157551954 @default.
- W1712202213 cites W2158665665 @default.
- W1712202213 cites W2160545120 @default.
- W1712202213 cites W2171780940 @default.
- W1712202213 cites W2172203092 @default.
- W1712202213 cites W2189215706 @default.
- W1712202213 cites W2502358406 @default.
- W1712202213 cites W4234317413 @default.
- W1712202213 doi "https://doi.org/10.1111/mmi.12236" @default.
- W1712202213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4081025" @default.
- W1712202213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23646936" @default.
- W1712202213 hasPublicationYear "2013" @default.
- W1712202213 type Work @default.
- W1712202213 sameAs 1712202213 @default.
- W1712202213 citedByCount "22" @default.
- W1712202213 countsByYear W17122022132013 @default.
- W1712202213 countsByYear W17122022132014 @default.
- W1712202213 countsByYear W17122022132015 @default.
- W1712202213 countsByYear W17122022132016 @default.
- W1712202213 countsByYear W17122022132017 @default.
- W1712202213 countsByYear W17122022132018 @default.
- W1712202213 countsByYear W17122022132019 @default.