Matches in SemOpenAlex for { <https://semopenalex.org/work/W1712224666> ?p ?o ?g. }
- W1712224666 endingPage "30" @default.
- W1712224666 startingPage "4525" @default.
- W1712224666 abstract "Kaposi's sarcoma-associated herpes virus (KSHV) infects B cells and microvascular endothelium,and is linked to both lymphoid and endothelial neoplasms. KSHV encodes a G protein-coupled receptor (v-GPCR) that can bind several CC and CXC chemokines but is able to signal in the absence of known ligands. This signaling can transform cultured fibroblasts, promote angiogenesis in vitro and in vivo, and activate the mitogen-activated protein kinase, c-Jun-NH(2)-terminal kinase, and p38 pathways. To assess the potential impact of v-GPCR signaling on host cell biology we have examined cellular gene expression in v-GPCR-transfected cells using DNA microarrays. v-GPCR expression up-regulated numerous cellular transcripts in both BJAB B cells and SLK endothelial cells, but with a remarkable degree of cell-type specificity. Among the most highly regulated genes in endothelial cells were the cytokines interleukin 6 and GRO alpha; several genes affecting endothelial/vascular growth and remodeling were also induced, including plasminogen, thrombomodulin, the urokinase-type plasminogen activator receptor, and to a modest extent vascular endothelial growth factor C. By contrast, the most highly regulated genes in B cells were the CC chemokines macrophage inflammatory protein 1 alpha and macrophage inflammatory protein 1 beta. No genes other than members of the dual-specificity phosphatase family were induced in both cell lines. The results indicate that the effects of KSHV GPCR expression in these two target cell types differ considerably and suggest that signaling by this molecule may make different contributions to the pathogenesis of KSHV-related endothelial and lymphoproliferative lesions." @default.
- W1712224666 created "2016-06-24" @default.
- W1712224666 creator A5000505153 @default.
- W1712224666 creator A5022150086 @default.
- W1712224666 creator A5026274834 @default.
- W1712224666 creator A5039824565 @default.
- W1712224666 date "2002-08-01" @default.
- W1712224666 modified "2023-09-23" @default.
- W1712224666 title "Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus." @default.
- W1712224666 cites W135187131 @default.
- W1712224666 cites W1483350500 @default.
- W1712224666 cites W1487939040 @default.
- W1712224666 cites W1488524199 @default.
- W1712224666 cites W1491026704 @default.
- W1712224666 cites W1501500713 @default.
- W1712224666 cites W1502936039 @default.
- W1712224666 cites W1548270485 @default.
- W1712224666 cites W1566845420 @default.
- W1712224666 cites W1587318259 @default.
- W1712224666 cites W160739290 @default.
- W1712224666 cites W1632068222 @default.
- W1712224666 cites W1955814101 @default.
- W1712224666 cites W1970339166 @default.
- W1712224666 cites W1973311715 @default.
- W1712224666 cites W1975535670 @default.
- W1712224666 cites W1979733640 @default.
- W1712224666 cites W1982047106 @default.
- W1712224666 cites W1988743962 @default.
- W1712224666 cites W1998340485 @default.
- W1712224666 cites W2003363521 @default.
- W1712224666 cites W2005220388 @default.
- W1712224666 cites W2014002032 @default.
- W1712224666 cites W2016845933 @default.
- W1712224666 cites W2029513848 @default.
- W1712224666 cites W2032438721 @default.
- W1712224666 cites W2037453625 @default.
- W1712224666 cites W2037857916 @default.
- W1712224666 cites W2040675530 @default.
- W1712224666 cites W2049070399 @default.
- W1712224666 cites W2053479489 @default.
- W1712224666 cites W2053631933 @default.
- W1712224666 cites W2056823054 @default.
- W1712224666 cites W2066418230 @default.
- W1712224666 cites W2068438824 @default.
- W1712224666 cites W2069624186 @default.
- W1712224666 cites W2071499027 @default.
- W1712224666 cites W2073537741 @default.
- W1712224666 cites W2074410605 @default.
- W1712224666 cites W2077416276 @default.
- W1712224666 cites W2082640307 @default.
- W1712224666 cites W2083846843 @default.
- W1712224666 cites W2086196885 @default.
- W1712224666 cites W2089097621 @default.
- W1712224666 cites W2090639515 @default.
- W1712224666 cites W2092101007 @default.
- W1712224666 cites W2094691874 @default.
- W1712224666 cites W2094885378 @default.
- W1712224666 cites W2102350205 @default.
- W1712224666 cites W2107445646 @default.
- W1712224666 cites W2107469531 @default.
- W1712224666 cites W2107599023 @default.
- W1712224666 cites W2119261083 @default.
- W1712224666 cites W2123045210 @default.
- W1712224666 cites W2123546970 @default.
- W1712224666 cites W2125479948 @default.
- W1712224666 cites W2132451996 @default.
- W1712224666 cites W2136402233 @default.
- W1712224666 cites W2136620152 @default.
- W1712224666 cites W2140921627 @default.
- W1712224666 cites W2141797212 @default.
- W1712224666 cites W2143090686 @default.
- W1712224666 cites W2144720739 @default.
- W1712224666 cites W2146519773 @default.
- W1712224666 cites W2149453948 @default.
- W1712224666 cites W2160976310 @default.
- W1712224666 cites W219613607 @default.
- W1712224666 cites W2323027157 @default.
- W1712224666 cites W2336241188 @default.
- W1712224666 cites W2340640662 @default.
- W1712224666 cites W238668910 @default.
- W1712224666 cites W2410723119 @default.
- W1712224666 cites W2414072355 @default.
- W1712224666 cites W2415108344 @default.
- W1712224666 cites W2441486213 @default.
- W1712224666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12154065" @default.
- W1712224666 hasPublicationYear "2002" @default.
- W1712224666 type Work @default.
- W1712224666 sameAs 1712224666 @default.
- W1712224666 citedByCount "28" @default.
- W1712224666 countsByYear W17122246662012 @default.
- W1712224666 countsByYear W17122246662013 @default.
- W1712224666 countsByYear W17122246662015 @default.
- W1712224666 countsByYear W17122246662022 @default.
- W1712224666 crossrefType "journal-article" @default.
- W1712224666 hasAuthorship W1712224666A5000505153 @default.
- W1712224666 hasAuthorship W1712224666A5022150086 @default.
- W1712224666 hasAuthorship W1712224666A5026274834 @default.
- W1712224666 hasAuthorship W1712224666A5039824565 @default.