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• W1712777744 abstract "BACKGROUND Surfactant has been shown to be dysfunctional in ARDS, and exogenous surfactant has proven effective in many forms of neonatal and pediatric acute lung injury (ALI). In view of the positive results of our studies in children along with evidence that surfactant-associated protein B containing pharmaceutical surfactants might be more effective, we designed a multiinstitutional, randomized, controlled, and masked trial of calfactant, a calf lung surfactant, in adults and children with ALI/ARDS due to direct lung injury. METHODS Adult subjects within 48 h of initiation of mechanical ventilation for direct ARDS were randomized to receive up to three interventions with instilled calfactant vs air placebo. The primary outcome was 90-day all-cause mortality. RESULTS Three hundred seventeen subjects were enrolled, 308 of whom could be evaluated. There were no significant baseline differences between groups. Calfactant administration was not associated with improved survival, lengths of stay, or oxygenation. Calfactant instillation was frequently associated with transient hypoxia and hypotension. The study was stopped at the first interim analysis at the sponsor's request. CONCLUSIONS Administration of calfactant was not associated with improved oxygenation or longer-term benefits relative to placebo in this randomized, controlled, and masked trial. At present, exogenous surfactant cannot be recommended for routine clinical use in ARDS. TRIAL REGISTRY ClinicalTrials.gov; No.: NCT00682500; URL: www.clinicaltrials.gov. Surfactant has been shown to be dysfunctional in ARDS, and exogenous surfactant has proven effective in many forms of neonatal and pediatric acute lung injury (ALI). In view of the positive results of our studies in children along with evidence that surfactant-associated protein B containing pharmaceutical surfactants might be more effective, we designed a multiinstitutional, randomized, controlled, and masked trial of calfactant, a calf lung surfactant, in adults and children with ALI/ARDS due to direct lung injury. Adult subjects within 48 h of initiation of mechanical ventilation for direct ARDS were randomized to receive up to three interventions with instilled calfactant vs air placebo. The primary outcome was 90-day all-cause mortality. Three hundred seventeen subjects were enrolled, 308 of whom could be evaluated. There were no significant baseline differences between groups. Calfactant administration was not associated with improved survival, lengths of stay, or oxygenation. Calfactant instillation was frequently associated with transient hypoxia and hypotension. The study was stopped at the first interim analysis at the sponsor's request. Administration of calfactant was not associated with improved oxygenation or longer-term benefits relative to placebo in this randomized, controlled, and masked trial. At present, exogenous surfactant cannot be recommended for routine clinical use in ARDS." @default.
• W1712777744 created "2016-06-24" @default.
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• W1712777744 date "2015-08-01" @default.
• W1712777744 modified "2023-10-11" @default.
• W1712777744 title "The Adult Calfactant in Acute Respiratory Distress Syndrome Trial" @default.
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• W1712777744 cites W1910726787 @default.
• W1712777744 cites W1940579175 @default.
• W1712777744 cites W1971305507 @default.
• W1712777744 cites W1974404062 @default.
• W1712777744 cites W1978249468 @default.
• W1712777744 cites W1990402565 @default.
• W1712777744 cites W1994204296 @default.
• W1712777744 cites W1994468600 @default.
• W1712777744 cites W2002354843 @default.
• W1712777744 cites W2011051154 @default.
• W1712777744 cites W2017371452 @default.
• W1712777744 cites W2018102891 @default.
• W1712777744 cites W2023199149 @default.
• W1712777744 cites W2030178631 @default.
• W1712777744 cites W2043713768 @default.
• W1712777744 cites W2045622557 @default.
• W1712777744 cites W2050585901 @default.
• W1712777744 cites W2059707463 @default.
• W1712777744 cites W2067506567 @default.
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• W1712777744 cites W2078364270 @default.
• W1712777744 cites W2083209568 @default.
• W1712777744 cites W2083412037 @default.
• W1712777744 cites W2084413144 @default.
• W1712777744 cites W2086858354 @default.
• W1712777744 cites W2099253666 @default.
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• W1712777744 cites W2133933468 @default.
• W1712777744 cites W2144964209 @default.
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• W1712777744 cites W2154581887 @default.
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• W1712777744 doi "https://doi.org/10.1378/chest.14-1139" @default.
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