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- W171282651 abstract "Investigations have been made into the use of a computer based simulationtechnique (Monte Carlo (MC)) to ionising radiation transport in order to verifythe doses delivered during linear accelerator based stereotactic radiotherapy andradiosurgery. Due to the complex nature of the micro multi-leaf collimators(�MLC) used in this these treatments, a bespoke model of the �MLC wasdeveloped and combined with standard component modules to represent theremainder of the linear accelerator.Following validation of the above models, investigations were made into thedosimetry of small fields, defined by the �MLC and measured with a varietyof detectors. Comparisons of relative output, profiles and depth doses weremade against MC simulations, and a series of correction factors determined, toaccount for detector geometry and the non water equivalence of materials usedin semiconductor detectors. An assessment was then made to determine thesmallest fields that can be measured with each detector with confidence.Systems were then developed to independently simulate stereotactictreatments and compare doses simulated with those calculated by the treatmentplanning system (TPS); excellent agreement between TPS calculations and MCsimulations was observed.The application of MC methods to determine the most appropriate treatmenttactics and calculation algorithms for stereotactic body radiotherapy in the lungwas then investigated with recommendations made on the most appropriatecalculation algorithms and beam arrangements for the technique. The dosescalculated using the type-b or collapsed cone algorithm agreed most closely withthe MC simulation. There was little difference observed between plans usingmore than four beams in the treatment delivery. Treatment techniques usingonly three beams or less achieved poorer coverage of the tumour with dose,producing lower doses at the periphery of the tumour near the interface with thesurrounding lung tissue, compared to using a greater number of beams.Finally, methods of transit dosimetry using Electronic Portal ImagingDevices were investigated for use in cranial stereotactic radiotherapy. Three methods were investigated based on a full MC simulation of the radiationtransport through the patient and on to the imager, prediction of the dose basedon a TPS calculation and an approximation of the radiological path length ofthe central axis of the beams to derive an expected dose at the imager plane.The MC method produced the best agreement at the expense of a longer timeto acquire the comparison doses compared to the TPS calculation method. Theequivalent path length method showed good agreement (within 3.5%) betweendelivered and predicted doses but at a single point." @default.
- W171282651 created "2016-06-24" @default.
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- W171282651 date "2011-01-01" @default.
- W171282651 modified "2023-09-26" @default.
- W171282651 title "Verification of stereotatic radiotherapy" @default.
- W171282651 hasPublicationYear "2011" @default.
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