FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1712893432> ?p ?o ?g. }

• W1712893432 endingPage "687" @default.
• W1712893432 startingPage "680" @default.
• W1712893432 abstract "We have characterized the cell-mediated and humoral immune response of patients with atopic dermatitis (AD) and healthy controls in response to two novel staphylococcal antigens (NP-tase, p70) and the superantigen staphylococcal enterotoxin B (SEB). The parameters studied were IgE, interleukin (IL)-4 and interferon (IFN)-γ synthesis by peripheral blood mononuclear cells (PBMC) after stimulation with NP-tase, p70 and SEB in vitro. Both antigens, as well as SEB, induced IL-4 and IFN-γ secretion in patients and controls. However, patients with AD showed a significantly diminished IFN-γ production in response to NP-tase or SEB. Furthermore, we demonstrated a good correlation between antigen-stimulated IgE production and the IL-4/IFN-γ ratio in vitro. A distinct subgroup of PBMC showed impaired IFN-γ synthesis and enhanced IL-4 secretion after incubation with p70 or NP-tase. These data support evidence that a subgroup of patients with AD, synthesizing low levels of IFN-γ after stimulation with staphylococcal antigens, may have impaired abilities to clear Staphylococcus aureus colonization. Persistent staphylococcal antigens could then be responsible for inflammatory and allergic skin reactions in patients with AD. We therefore conclude that, besides superantigens, staphylococcal antigens may also play a part in the pathogenesis of AD." @default.
• W1712893432 created "2016-06-24" @default.
• W1712893432 creator A5006054781 @default.
• W1712893432 creator A5047819787 @default.
• W1712893432 creator A5077400968 @default.
• W1712893432 date "2000-04-01" @default.
• W1712893432 modified "2023-10-16" @default.
• W1712893432 title "Effects of two novel cationic staphylococcal proteins (NP-taseand p70) and enterotoxin B on IgE synthesis and interleukin-4 and interferon-γ production in patients with atopic dermatitis" @default.
• W1712893432 cites W1544778450 @default.
• W1712893432 cites W1974530989 @default.
• W1712893432 cites W1974682549 @default.
• W1712893432 cites W1978974605 @default.
• W1712893432 cites W1979799895 @default.
• W1712893432 cites W1985977440 @default.
• W1712893432 cites W1988974585 @default.
• W1712893432 cites W1990989893 @default.
• W1712893432 cites W1999023729 @default.
• W1712893432 cites W1999243330 @default.
• W1712893432 cites W2016834096 @default.
• W1712893432 cites W2020977425 @default.
• W1712893432 cites W2029456813 @default.
• W1712893432 cites W2036831826 @default.
• W1712893432 cites W2040079542 @default.
• W1712893432 cites W2052828401 @default.
• W1712893432 cites W2054281643 @default.
• W1712893432 cites W2061581524 @default.
• W1712893432 cites W2062230786 @default.
• W1712893432 cites W2064350506 @default.
• W1712893432 cites W2086417745 @default.
• W1712893432 cites W2094675700 @default.
• W1712893432 cites W2099791606 @default.
• W1712893432 cites W2114228213 @default.
• W1712893432 cites W2129418984 @default.
• W1712893432 cites W2143138262 @default.
• W1712893432 cites W2169128022 @default.
• W1712893432 doi "https://doi.org/10.1046/j.1365-2133.2000.03412.x" @default.
• W1712893432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10792217" @default.
• W1712893432 hasPublicationYear "2000" @default.
• W1712893432 type Work @default.
• W1712893432 sameAs 1712893432 @default.
• W1712893432 citedByCount "27" @default.
• W1712893432 countsByYear W17128934322016 @default.
• W1712893432 countsByYear W17128934322019 @default.
• W1712893432 crossrefType "journal-article" @default.
• W1712893432 hasAuthorship W1712893432A5006054781 @default.
• W1712893432 hasAuthorship W1712893432A5047819787 @default.
• W1712893432 hasAuthorship W1712893432A5077400968 @default.
• W1712893432 hasConcept C104317684 @default.
• W1712893432 hasConcept C137061746 @default.
• W1712893432 hasConcept C141105273 @default.
• W1712893432 hasConcept C147483822 @default.
• W1712893432 hasConcept C159654299 @default.
• W1712893432 hasConcept C202751555 @default.
• W1712893432 hasConcept C203014093 @default.
• W1712893432 hasConcept C2776090121 @default.
• W1712893432 hasConcept C2778329239 @default.
• W1712893432 hasConcept C36333154 @default.
• W1712893432 hasConcept C547475151 @default.
• W1712893432 hasConcept C55493867 @default.
• W1712893432 hasConcept C66999527 @default.
• W1712893432 hasConcept C71924100 @default.
• W1712893432 hasConcept C86803240 @default.
• W1712893432 hasConcept C8891405 @default.
• W1712893432 hasConcept C89423630 @default.
• W1712893432 hasConceptScore W1712893432C104317684 @default.
• W1712893432 hasConceptScore W1712893432C137061746 @default.
• W1712893432 hasConceptScore W1712893432C141105273 @default.
• W1712893432 hasConceptScore W1712893432C147483822 @default.
• W1712893432 hasConceptScore W1712893432C159654299 @default.
• W1712893432 hasConceptScore W1712893432C202751555 @default.
• W1712893432 hasConceptScore W1712893432C203014093 @default.
• W1712893432 hasConceptScore W1712893432C2776090121 @default.
• W1712893432 hasConceptScore W1712893432C2778329239 @default.
• W1712893432 hasConceptScore W1712893432C36333154 @default.
• W1712893432 hasConceptScore W1712893432C547475151 @default.
• W1712893432 hasConceptScore W1712893432C55493867 @default.
• W1712893432 hasConceptScore W1712893432C66999527 @default.
• W1712893432 hasConceptScore W1712893432C71924100 @default.
• W1712893432 hasConceptScore W1712893432C86803240 @default.
• W1712893432 hasConceptScore W1712893432C8891405 @default.
• W1712893432 hasConceptScore W1712893432C89423630 @default.
• W1712893432 hasIssue "4" @default.
• W1712893432 hasLocation W17128934321 @default.
• W1712893432 hasLocation W17128934322 @default.
• W1712893432 hasOpenAccess W1712893432 @default.
• W1712893432 hasPrimaryLocation W17128934321 @default.
• W1712893432 hasRelatedWork W1991366940 @default.
• W1712893432 hasRelatedWork W2026919120 @default.
• W1712893432 hasRelatedWork W2031687972 @default.
• W1712893432 hasRelatedWork W2032890559 @default.
• W1712893432 hasRelatedWork W2037061026 @default.
• W1712893432 hasRelatedWork W2047218659 @default.
• W1712893432 hasRelatedWork W2145150068 @default.
• W1712893432 hasRelatedWork W2382752755 @default.
• W1712893432 hasRelatedWork W2526301464 @default.
• W1712893432 hasRelatedWork W4238956724 @default.
• W1712893432 hasVolume "142" @default.
• W1712893432 isParatext "false" @default.

• next