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- W1713674711 abstract "Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres Sk Md Athar AlliDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, IndiaAbstract: Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose, a mucoadhesive polymer, following coacervation and phase separation technique and were subsequently enteric-coated with hypromellose phthalate. Microspheres were evaluated for percent yield; entrapment efficiency; in vitro swelling; surface morphology; particle size, size distribution, and zeta potential; flow property, mucoadhesion property by the ex vivo mucoadhesive strength test and the in vitro wash off test; in vitro release profile and release kinetic; in vivo probiotic activity; and stability. The values for the kinetic constant and regression coefficient of model-dependent approaches and the difference factor ( ƒ1), the similarity factor (ƒ2), and the Rescigno index (ξ1 and ξ 2) of model independent approaches were determined for comparing in vitro dissolution profiles. Freeze dried B. coagulans cells were successfully formulated as enteric-coated mucoadhesive microspheres with satisfactory physical structure and yield. The viability of B. coagulans was maintained in the simulated gastric conditions and during processing; in simulated intestinal conditions exhibiting mucoadhesion, and controlling and extending the viable cell release following zero-order; and was satisfactorily stable at room temperature. Test results depict statistically significant effects of the hypromellose grade and their concentration on the performance and release profile of formulations.Keywords: probiotics, B. coagulans, mucoadhesive, microspheres, extended-release" @default.
- W1713674711 created "2016-06-24" @default.
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- W1713674711 date "2011-03-01" @default.
- W1713674711 modified "2023-09-30" @default.
- W1713674711 title "Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres" @default.
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- W1713674711 doi "https://doi.org/10.2147/ijn.s14621" @default.
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