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- W171386802 abstract "Longitudinal changes in cerebral volume have been described in ischaemic stroke and may correlate with long-term outcome. We tested the hypothesis that baseline peri-infarct concentration of the neuronal metabolite N-acetylaspartic acid (NAA) correlates with subsequent cerebral volume change after stroke. Patients with supratentorial ischaemic stroke underwent 3 Tesla MRI within 1 week and at 1 and 3 months from onset. Structural imaging involved a T1-weighted axial magnetization prepared rapid gradient echo (1 mm slices, repetition time 1.9 s, echo time 2.82 ms). NAA estimation was performed at baseline using single-voxel spectroscopy (3 × 3 × 3 cm voxels, echo time 30 ms) with the voxel placed in the peri-infarct region determined by visual assessment of the diffusion-weighted image. Quantitative spectroscopic analysis was performed in LCmodel. Cerebral volume change was determined between the 1 and 3 month scans due to the effects of oedema on baseline scans. Grey and white matter volume, normalised for head size, were determined using SIENAX (part of FSL). The result was validated using Freesurfer. Fifteen patients were included in the analysis. Mean age was 69 years (interwquartile range [IQR] 62–78). Median baseline National Institutes of Health Stroke Scale score was 10 (IQR 5–14). Mean peri-infarct NAA concentration was 6.2 mM (IQR 5.1–7.6) versus 7.0 mM (IQR 6.0–8.0) in the contralateral hemisphere (p" @default.
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- W171386802 date "2014-11-01" @default.
- W171386802 modified "2023-09-27" @default.
- W171386802 title "32." @default.
- W171386802 doi "https://doi.org/10.1016/j.jocn.2014.06.046" @default.
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