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- W1713895945 abstract "Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT in the cerebral cortex by immunohistochemistry, and of barrels, both at P7 and adulthood. Quantitative electron microscopy reveals that 5-HTT ko affects neither the density of synapses nor the length of synaptic contacts in layer IV. VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not." @default.
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- W1713895945 date "2001-09-01" @default.
- W1713895945 modified "2023-10-11" @default.
- W1713895945 title "Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release" @default.
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- W1713895945 doi "https://doi.org/10.1523/jneurosci.21-17-06862.2001" @default.
- W1713895945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763105" @default.
- W1713895945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11517274" @default.
- W1713895945 hasPublicationYear "2001" @default.