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• W1714042500 abstract "Research Article1 September 1992free access Evolution of the primate lentiviruses: evidence from vpx and vpr. M. Tristem M. Tristem Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author C. Marshall C. Marshall Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author A. Karpas A. Karpas Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author F. Hill F. Hill Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author M. Tristem M. Tristem Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author C. Marshall C. Marshall Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author A. Karpas A. Karpas Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author F. Hill F. Hill Department of Haematology, University of Cambridge Clinical School, UK. Search for more papers by this author Author Information M. Tristem1, C. Marshall1, A. Karpas1 and F. Hill1 1Department of Haematology, University of Cambridge Clinical School, UK. The EMBO Journal (1992)11:3405-3412https://doi.org/10.1002/j.1460-2075.1992.tb05419.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The genomes of the four primate lentiviral groups are complex and contain several regulatory or accessory genes. Two of these genes, vpr and vpx, are found in various combinations within the four groups and encode proteins whose functions have yet to be elucidated. Comparison of the encoded protein sequences suggests that the vpx gene within the HIV-2 group arose by the duplication of an ancestral vpr gene within this group. Evolutionary distance analysis showed that both genes were well conserved when compared with viral regulatory genes, and indicated that the duplication occurred at approximately the same time as the HIV-2 group and the other primate lentivirus groups diverged from a common ancestor. Furthermore, although the SIVagm vpx proteins are homologous to the HIV-2 group vpx proteins, there are insufficient grounds from sequence analysis for classifying them as vpx proteins. Because of their similarity to the vpr proteins of other groups, we suggest reclassifying the SIVagm vpx gene as a vpr gene. This creates a simpler and more uniform picture of the genomic organization of the primate lentiviruses and allows the genomic organization of their common precursor to be defined; it probably contained five accessory genes: tat, rev, vif, nef and vpr. Previous ArticleNext Article Volume 11Issue 91 September 1992In this issue RelatedDetailsLoading ..." @default.
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• W1714042500 date "1992-09-01" @default.
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• W1714042500 title "Evolution of the primate lentiviruses: evidence from vpx and vpr." @default.
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• W1714042500 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05419.x" @default.
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