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- W1714643306 abstract "Lindebjerg J, Hansborg N, Ploen J, Rafaelsen S, Jorgensen J C R & Jakobsen A(2011) Histopathology59, 18–21 Factors influencing reproducibility of tumour regression grading after high-dose chemoradiation of locally advanced rectal cancer Aims: High-dose chemoradiation is now considered the standard treatment of locally advanced rectal cancer. To provide feedback on the effect of this treatment, several regression grading systems have been proposed. For a grading system to be useful it has to be reproducible. The aim of this study was to test the reproducibility of a five-point grading system, proposed originally by Mandard, and to describe the sources of disagreement. Methods and results: Tumour regression was assessed independently by two observers on 100 consecutive chemoradiated rectal cancer specimens. The grading system was extremely reproducible, with weighted and unweighted kappa values of 0.89 and 0.82, respectively. The most frequent source of disagreement was assessment of the relative amount of fibrosis. Displacement of epithelium was a minor source of disagreement. Conclusions: The five-point grading system of Mandard is extremely reproducible." @default.
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- W1714643306 date "2011-07-01" @default.
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- W1714643306 title "Factors influencing reproducibility of tumour regression grading after high-dose chemoradiation of locally advanced rectal cancer" @default.
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- W1714643306 doi "https://doi.org/10.1111/j.1365-2559.2011.03888.x" @default.
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