FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1714774488> ?p ?o ?g. }

• W1714774488 endingPage "2797" @default.
• W1714774488 startingPage "2791" @default.
• W1714774488 abstract "To prevent complement-mediated autologous tissue damage, host cells express a number of membrane-bound complement inhibitors. Decay-accelerating factor (DAF, CD55) is a GPI-linked membrane complement regulator that is widely expressed in mammalian tissues including the kidney. DAF inhibits the C3 convertase of both the classical and alternative pathways. Although DAF deficiency contributes to the human hematological syndrome paroxysmal nocturnal hemoglobinuria, the relevance of DAF in autoimmune tissue damage such as immune glomerulonephritis remains to be determined. In this study, we have investigated the susceptibility of knockout mice that are deficient in GPI-anchored DAF to nephrotoxic serum nephritis. Injection of a subnephritogenic dose of rabbit anti-mouse glomerular basement membrane serum induced glomerular disease in DAF knockout mice but not in wild-type controls. When examined at 8 days after anti-glomerular basement membrane treatment, DAF knockout mice had a much higher percentage of diseased glomeruli than wild-type mice (68.8 +/- 25.0 vs 10.0 +/- 3.5%; p < 0.01). Morphologically, DAF knockout mice displayed increased glomerular volume (516 +/- 68 vs 325 +/- 18 x 10(3) microm(3) per glomerulus; p < 0.0001) and cellularity (47.1 +/- 8.9 vs 32.0 +/- 3.1 cells per glomerulus; p < 0.01). Although the blood urea nitrogen level showed no difference between the two groups, proteinuria was observed in the knockout mice but not in the wild-type mice (1.4 +/- 0.7 vs 0.02 +/- 0.01 mg/24 h albumin excretion). The morphological and functional abnormalities in the knockout mouse kidney were associated with evidence of increased complement activation in the glomeruli. These results support the conclusion that membrane C3 convertase inhibitors like DAF play a protective role in complement-mediated immune glomerular damage in vivo." @default.
• W1714774488 created "2016-06-24" @default.
• W1714774488 creator A5007361141 @default.
• W1714774488 creator A5013389489 @default.
• W1714774488 creator A5031632066 @default.
• W1714774488 creator A5036113498 @default.
• W1714774488 creator A5059943171 @default.
• W1714774488 creator A5078197541 @default.
• W1714774488 creator A5080266991 @default.
• W1714774488 creator A5083684950 @default.
• W1714774488 creator A5089587112 @default.
• W1714774488 date "2001-09-01" @default.
• W1714774488 modified "2023-10-04" @default.
• W1714774488 title "Increased Susceptibility of Decay-Accelerating Factor Deficient Mice to Anti-Glomerular Basement Membrane Glomerulonephritis" @default.
• W1714774488 cites W1483924912 @default.
• W1714774488 cites W1513100518 @default.
• W1714774488 cites W1514500363 @default.
• W1714774488 cites W1537414502 @default.
• W1714774488 cites W1554698729 @default.
• W1714774488 cites W1567784487 @default.
• W1714774488 cites W1594470430 @default.
• W1714774488 cites W1615315558 @default.
• W1714774488 cites W1839131783 @default.
• W1714774488 cites W1872408728 @default.
• W1714774488 cites W1938137317 @default.
• W1714774488 cites W1974305168 @default.
• W1714774488 cites W1979236750 @default.
• W1714774488 cites W1980900674 @default.
• W1714774488 cites W1981659654 @default.
• W1714774488 cites W1992772811 @default.
• W1714774488 cites W2001664656 @default.
• W1714774488 cites W2005328294 @default.
• W1714774488 cites W2007642085 @default.
• W1714774488 cites W2008158047 @default.
• W1714774488 cites W2009387411 @default.
• W1714774488 cites W2022206774 @default.
• W1714774488 cites W2029007870 @default.
• W1714774488 cites W2041326076 @default.
• W1714774488 cites W2043597009 @default.
• W1714774488 cites W2048538843 @default.
• W1714774488 cites W2049506974 @default.
• W1714774488 cites W2052103695 @default.
• W1714774488 cites W2059500339 @default.
• W1714774488 cites W2071468645 @default.
• W1714774488 cites W2072990621 @default.
• W1714774488 cites W2073755366 @default.
• W1714774488 cites W2075780443 @default.
• W1714774488 cites W2083031926 @default.
• W1714774488 cites W2085406842 @default.
• W1714774488 cites W2088018465 @default.
• W1714774488 cites W2094049563 @default.
• W1714774488 cites W2095634647 @default.
• W1714774488 cites W2104199760 @default.
• W1714774488 cites W2106049483 @default.
• W1714774488 cites W2127425255 @default.
• W1714774488 cites W2138495171 @default.
• W1714774488 cites W2144144568 @default.
• W1714774488 cites W2152109529 @default.
• W1714774488 cites W2152621712 @default.
• W1714774488 cites W2154442199 @default.
• W1714774488 cites W2155571650 @default.
• W1714774488 cites W2167386744 @default.
• W1714774488 cites W2178334364 @default.
• W1714774488 cites W2420691662 @default.
• W1714774488 cites W2432049464 @default.
• W1714774488 cites W4248036201 @default.
• W1714774488 cites W4299710192 @default.
• W1714774488 cites W4313341453 @default.
• W1714774488 doi "https://doi.org/10.4049/jimmunol.167.5.2791" @default.
• W1714774488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11509624" @default.
• W1714774488 hasPublicationYear "2001" @default.
• W1714774488 type Work @default.
• W1714774488 sameAs 1714774488 @default.
• W1714774488 citedByCount "79" @default.
• W1714774488 countsByYear W17147744882012 @default.
• W1714774488 countsByYear W17147744882014 @default.
• W1714774488 countsByYear W17147744882015 @default.
• W1714774488 countsByYear W17147744882016 @default.
• W1714774488 countsByYear W17147744882018 @default.
• W1714774488 countsByYear W17147744882019 @default.
• W1714774488 countsByYear W17147744882021 @default.
• W1714774488 countsByYear W17147744882022 @default.
• W1714774488 crossrefType "journal-article" @default.
• W1714774488 hasAuthorship W1714774488A5007361141 @default.
• W1714774488 hasAuthorship W1714774488A5013389489 @default.
• W1714774488 hasAuthorship W1714774488A5031632066 @default.
• W1714774488 hasAuthorship W1714774488A5036113498 @default.
• W1714774488 hasAuthorship W1714774488A5059943171 @default.
• W1714774488 hasAuthorship W1714774488A5078197541 @default.
• W1714774488 hasAuthorship W1714774488A5080266991 @default.
• W1714774488 hasAuthorship W1714774488A5083684950 @default.
• W1714774488 hasAuthorship W1714774488A5089587112 @default.
• W1714774488 hasBestOaLocation W17147744881 @default.
• W1714774488 hasConcept C111684460 @default.
• W1714774488 hasConcept C126322002 @default.
• W1714774488 hasConcept C134018914 @default.
• W1714774488 hasConcept C170493617 @default.
• W1714774488 hasConcept C182704531 @default.

• next