Matches in SemOpenAlex for { <https://semopenalex.org/work/W1714807130> ?p ?o ?g. }
- W1714807130 endingPage "13370" @default.
- W1714807130 startingPage "13359" @default.
- W1714807130 abstract "Homeoproteins, a family of transcription factors that have conserved homeobox domains, play critical roles in embryonic development in a wide range of species. Accumulating studies have revealed that homeoproteins are aberrantly expressed in multiple tumors and function as either tumor promoters or suppressors. In this study, we show that two homeoproteins, HOXB13 and ALX4, are associated with epithelial to mesenchymal transition (EMT) and invasion of ovarian cancer cells. HOXB13 and ALX4 formed a complex in cells, and exogenous expression of either protein promoted EMT and invasion. Conversely, depletion of either protein suppressed invasion and induced reversion of EMT. SLUG is a C2H2-type zinc-finger transcription factor that promotes EMT in various cell lines. Knockdown of HOXB13 or ALX4 suppressed SLUG expression, and exogenous expression of either protein promoted SLUG expression. Finally, we showed that SLUG expression was essential for the HOXB13- or ALX4-mediated EMT and invasion. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells." @default.
- W1714807130 created "2016-06-24" @default.
- W1714807130 creator A5021170427 @default.
- W1714807130 creator A5022780568 @default.
- W1714807130 creator A5042917323 @default.
- W1714807130 creator A5058903905 @default.
- W1714807130 creator A5073313983 @default.
- W1714807130 creator A5078465675 @default.
- W1714807130 creator A5078859785 @default.
- W1714807130 creator A5087687564 @default.
- W1714807130 date "2015-04-10" @default.
- W1714807130 modified "2023-10-16" @default.
- W1714807130 title "HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells" @default.
- W1714807130 cites W1531095847 @default.
- W1714807130 cites W1574155225 @default.
- W1714807130 cites W1593447645 @default.
- W1714807130 cites W1740119976 @default.
- W1714807130 cites W1930346508 @default.
- W1714807130 cites W1966614713 @default.
- W1714807130 cites W1976209715 @default.
- W1714807130 cites W1980136456 @default.
- W1714807130 cites W1982358201 @default.
- W1714807130 cites W1985348819 @default.
- W1714807130 cites W1988141621 @default.
- W1714807130 cites W1988699811 @default.
- W1714807130 cites W1992707318 @default.
- W1714807130 cites W2000368359 @default.
- W1714807130 cites W2000791725 @default.
- W1714807130 cites W2003215649 @default.
- W1714807130 cites W2003738260 @default.
- W1714807130 cites W2011880293 @default.
- W1714807130 cites W2013126388 @default.
- W1714807130 cites W2023640842 @default.
- W1714807130 cites W2025918688 @default.
- W1714807130 cites W2030229287 @default.
- W1714807130 cites W2035411415 @default.
- W1714807130 cites W2035661568 @default.
- W1714807130 cites W2037910321 @default.
- W1714807130 cites W2048546181 @default.
- W1714807130 cites W2050969216 @default.
- W1714807130 cites W2054364834 @default.
- W1714807130 cites W2059775083 @default.
- W1714807130 cites W2060564659 @default.
- W1714807130 cites W2062880716 @default.
- W1714807130 cites W2072319964 @default.
- W1714807130 cites W2073940524 @default.
- W1714807130 cites W2076002185 @default.
- W1714807130 cites W2077135823 @default.
- W1714807130 cites W2079360110 @default.
- W1714807130 cites W2083756787 @default.
- W1714807130 cites W2083992760 @default.
- W1714807130 cites W2096966618 @default.
- W1714807130 cites W2102902836 @default.
- W1714807130 cites W2113860186 @default.
- W1714807130 cites W2116578290 @default.
- W1714807130 cites W2120039528 @default.
- W1714807130 cites W2121475173 @default.
- W1714807130 cites W2130550193 @default.
- W1714807130 cites W2131944740 @default.
- W1714807130 cites W2138608775 @default.
- W1714807130 cites W2139780561 @default.
- W1714807130 cites W2140959656 @default.
- W1714807130 cites W2147751805 @default.
- W1714807130 cites W2151392483 @default.
- W1714807130 cites W2167266367 @default.
- W1714807130 cites W2170822975 @default.
- W1714807130 cites W2178232667 @default.
- W1714807130 cites W2186560096 @default.
- W1714807130 doi "https://doi.org/10.18632/oncotarget.3673" @default.
- W1714807130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4537020" @default.
- W1714807130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25944620" @default.
- W1714807130 hasPublicationYear "2015" @default.
- W1714807130 type Work @default.
- W1714807130 sameAs 1714807130 @default.
- W1714807130 citedByCount "31" @default.
- W1714807130 countsByYear W17148071302016 @default.
- W1714807130 countsByYear W17148071302017 @default.
- W1714807130 countsByYear W17148071302018 @default.
- W1714807130 countsByYear W17148071302019 @default.
- W1714807130 countsByYear W17148071302020 @default.
- W1714807130 countsByYear W17148071302021 @default.
- W1714807130 countsByYear W17148071302022 @default.
- W1714807130 countsByYear W17148071302023 @default.
- W1714807130 crossrefType "journal-article" @default.
- W1714807130 hasAuthorship W1714807130A5021170427 @default.
- W1714807130 hasAuthorship W1714807130A5022780568 @default.
- W1714807130 hasAuthorship W1714807130A5042917323 @default.
- W1714807130 hasAuthorship W1714807130A5058903905 @default.
- W1714807130 hasAuthorship W1714807130A5073313983 @default.
- W1714807130 hasAuthorship W1714807130A5078465675 @default.
- W1714807130 hasAuthorship W1714807130A5078859785 @default.
- W1714807130 hasAuthorship W1714807130A5087687564 @default.
- W1714807130 hasBestOaLocation W17148071301 @default.
- W1714807130 hasConcept C104317684 @default.
- W1714807130 hasConcept C121587040 @default.
- W1714807130 hasConcept C121608353 @default.
- W1714807130 hasConcept C173396325 @default.
- W1714807130 hasConcept C2779013556 @default.