Matches in SemOpenAlex for { <https://semopenalex.org/work/W1714917620> ?p ?o ?g. }
- W1714917620 endingPage "1648" @default.
- W1714917620 startingPage "1627" @default.
- W1714917620 abstract "Introduction: Current immunosuppressive combination therapy provides excellent prevention of T-cell-mediated rejection following renal transplantation; however, antibody-mediated rejection remains of high concern and accounts for a large number of long-term allograft losses. The recent development of protocol biopsies resulted in the definition of subclinical rejection (SCR), showing histologic evidence for rejection but unremarkable clinical course.Areas covered: This review describes the current knowledge and evidence of pharmacotherapy to treat kidney allograft rejections and covers SCR treatment options. Each substance is analyzed with regard to its classical indication and further discussed for the treatment of other forms of rejection.Expert opinion: Despite a lack of randomized trials, early acute T-cell-mediated rejection can be treated effectively in most cases without graft loss. The necessity to treat SCR is currently unclear. Due to a lack of effective therapies, new treatment approaches for antibody-mediated rejection are an urgent medical need to improve long-term outcomes. Future research should aim to better define pathophysiology and histology, stratify risk, and develop rational treatment strategies from randomized controlled trials, in order to establish the value of novel therapies in the arsenal of rejection pharmacotherapy. However, the effective prevention of rejection with minimal side effects still remains the goal in immunosuppression." @default.
- W1714917620 created "2016-06-24" @default.
- W1714917620 creator A5005911928 @default.
- W1714917620 creator A5006846469 @default.
- W1714917620 creator A5006987359 @default.
- W1714917620 creator A5013136974 @default.
- W1714917620 creator A5033636816 @default.
- W1714917620 creator A5055798055 @default.
- W1714917620 creator A5060425510 @default.
- W1714917620 creator A5071609615 @default.
- W1714917620 creator A5091559393 @default.
- W1714917620 date "2015-07-09" @default.
- W1714917620 modified "2023-10-04" @default.
- W1714917620 title "Advances in pharmacotherapy to treat kidney transplant rejection" @default.
- W1714917620 cites W1480967779 @default.
- W1714917620 cites W1486598251 @default.
- W1714917620 cites W1496154285 @default.
- W1714917620 cites W1506151781 @default.
- W1714917620 cites W1506252195 @default.
- W1714917620 cites W1510382284 @default.
- W1714917620 cites W1512745446 @default.
- W1714917620 cites W1531975610 @default.
- W1714917620 cites W1533163737 @default.
- W1714917620 cites W1544648272 @default.
- W1714917620 cites W1549634481 @default.
- W1714917620 cites W1551454296 @default.
- W1714917620 cites W1554670304 @default.
- W1714917620 cites W1566672148 @default.
- W1714917620 cites W1588284792 @default.
- W1714917620 cites W1590656518 @default.
- W1714917620 cites W1656025217 @default.
- W1714917620 cites W1737600104 @default.
- W1714917620 cites W1753626413 @default.
- W1714917620 cites W1760432558 @default.
- W1714917620 cites W1779151064 @default.
- W1714917620 cites W1788698477 @default.
- W1714917620 cites W1800865930 @default.
- W1714917620 cites W1822907261 @default.
- W1714917620 cites W1841260158 @default.
- W1714917620 cites W1858780699 @default.
- W1714917620 cites W1865874319 @default.
- W1714917620 cites W1905489641 @default.
- W1714917620 cites W1916860342 @default.
- W1714917620 cites W1922868692 @default.
- W1714917620 cites W1935012135 @default.
- W1714917620 cites W1963935236 @default.
- W1714917620 cites W1964145194 @default.
- W1714917620 cites W1968700398 @default.
- W1714917620 cites W1968998293 @default.
- W1714917620 cites W1969595451 @default.
- W1714917620 cites W1970280471 @default.
- W1714917620 cites W1971278669 @default.
- W1714917620 cites W1971888578 @default.
- W1714917620 cites W1972927083 @default.
- W1714917620 cites W1973549437 @default.
- W1714917620 cites W1976333624 @default.
- W1714917620 cites W1976474080 @default.
- W1714917620 cites W1977978637 @default.
- W1714917620 cites W1978362461 @default.
- W1714917620 cites W1980401398 @default.
- W1714917620 cites W1982528317 @default.
- W1714917620 cites W1984811897 @default.
- W1714917620 cites W1985075809 @default.
- W1714917620 cites W1985452640 @default.
- W1714917620 cites W1986037486 @default.
- W1714917620 cites W1987349895 @default.
- W1714917620 cites W1987999831 @default.
- W1714917620 cites W1988652338 @default.
- W1714917620 cites W1989518522 @default.
- W1714917620 cites W1989569525 @default.
- W1714917620 cites W1991050664 @default.
- W1714917620 cites W1992810159 @default.
- W1714917620 cites W1993204859 @default.
- W1714917620 cites W1994002700 @default.
- W1714917620 cites W1994399468 @default.
- W1714917620 cites W1994895013 @default.
- W1714917620 cites W1995791071 @default.
- W1714917620 cites W1996165238 @default.
- W1714917620 cites W1997244864 @default.
- W1714917620 cites W1997331942 @default.
- W1714917620 cites W1998099663 @default.
- W1714917620 cites W1999123359 @default.
- W1714917620 cites W2000174571 @default.
- W1714917620 cites W2000531481 @default.
- W1714917620 cites W2001020350 @default.
- W1714917620 cites W2001778847 @default.
- W1714917620 cites W2002905931 @default.
- W1714917620 cites W2004913375 @default.
- W1714917620 cites W2005170044 @default.
- W1714917620 cites W2005620560 @default.
- W1714917620 cites W2006210549 @default.
- W1714917620 cites W2007021990 @default.
- W1714917620 cites W2010368108 @default.
- W1714917620 cites W2011070152 @default.
- W1714917620 cites W2011911900 @default.
- W1714917620 cites W2011912275 @default.
- W1714917620 cites W2012366895 @default.
- W1714917620 cites W2012571571 @default.