FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1716174983> ?p ?o ?g. }

• W1716174983 endingPage "1283" @default.
• W1716174983 startingPage "1270" @default.
• W1716174983 abstract "The developing brain of a neonate is particularly susceptible to damage by vitamin C deficiency because of its rapid growth and immature antioxidant system. Cognitive impairment and sensory motor deficits are found in the adult brain upon vitamin C deficiency. Therefore, the aim of this study was to clarify the role of vitamin C in its own right and its related mechanisms in Gulo(-/-) mice incapable of synthesizing vitamin C.When vitamin C supplementation was ceased for 2 weeks until delivery, stillbirths and a significant reduction in neonatal mice were observed and the growth of neonates was remarkably decreased. In addition, intraparenchymal hemorrhages were found in most of the brains, especially in the stillborn neonates. In addition, the levels of malondialdehyde (MDA) and 8-isoprostanes were increased and structural abnormalities were found in the cortex, hippocampus, and cerebellum. Especially, vitamin C deficiency caused the failure of or a delay in the formation of cerebellar fissures accompanied by abnormal foliation and altered Purkinje cell alignment. In the developed adult brains from vitamin C-deficient Gulo(-/-) mice, the levels of glutathione, MDA, nitrate, IL-6, TNF-α, and Bax were increased and the expression of the GABRA6 and calbindin-28k was decreased. Due to atrophy of the granule and Purkinje cells, the motor behavior of vitamin C-deficient Gulo(-/-) mice declined.Vitamin C deficiency during gestation induces intraparenchymal hemorrhages and severe defects in the development of the cerebellum. In fully developed brains, it induces the functional impairment by altering the cellular composition in the cerebellum." @default.
• W1716174983 created "2016-06-24" @default.
• W1716174983 creator A5005163834 @default.
• W1716174983 creator A5007122170 @default.
• W1716174983 creator A5015413361 @default.
• W1716174983 creator A5025050406 @default.
• W1716174983 creator A5034506469 @default.
• W1716174983 creator A5037389442 @default.
• W1716174983 creator A5037738610 @default.
• W1716174983 creator A5060215799 @default.
• W1716174983 creator A5081993898 @default.
• W1716174983 creator A5087648509 @default.
• W1716174983 date "2015-12-01" @default.
• W1716174983 modified "2023-10-15" @default.
• W1716174983 title "Vitamin C Deficiency Causes Severe Defects in the Development of the Neonatal Cerebellum and in the Motor Behaviors of<i>Gulo^−/−</i>Mice" @default.
• W1716174983 cites W1214650195 @default.
• W1716174983 cites W1511302815 @default.
• W1716174983 cites W1517698775 @default.
• W1716174983 cites W1534880720 @default.
• W1716174983 cites W1812391321 @default.
• W1716174983 cites W1858019207 @default.
• W1716174983 cites W1969315375 @default.
• W1716174983 cites W1969385847 @default.
• W1716174983 cites W1969982879 @default.
• W1716174983 cites W1973602321 @default.
• W1716174983 cites W1978088063 @default.
• W1716174983 cites W1980433493 @default.
• W1716174983 cites W1980742896 @default.
• W1716174983 cites W1985388043 @default.
• W1716174983 cites W1986282201 @default.
• W1716174983 cites W1987039001 @default.
• W1716174983 cites W1987455406 @default.
• W1716174983 cites W1993250284 @default.
• W1716174983 cites W1994660225 @default.
• W1716174983 cites W1996621445 @default.
• W1716174983 cites W1997409763 @default.
• W1716174983 cites W1999688843 @default.
• W1716174983 cites W2003410549 @default.
• W1716174983 cites W2005794444 @default.
• W1716174983 cites W2008092267 @default.
• W1716174983 cites W2011152776 @default.
• W1716174983 cites W2019256890 @default.
• W1716174983 cites W2023219601 @default.
• W1716174983 cites W2032213742 @default.
• W1716174983 cites W2038561595 @default.
• W1716174983 cites W2039379548 @default.
• W1716174983 cites W2046036275 @default.
• W1716174983 cites W2051849819 @default.
• W1716174983 cites W2053099858 @default.
• W1716174983 cites W2053797841 @default.
• W1716174983 cites W2058747924 @default.
• W1716174983 cites W2058824016 @default.
• W1716174983 cites W2062161568 @default.
• W1716174983 cites W2065016714 @default.
• W1716174983 cites W2065528657 @default.
• W1716174983 cites W2067380913 @default.
• W1716174983 cites W2072801925 @default.
• W1716174983 cites W2084006368 @default.
• W1716174983 cites W2084500917 @default.
• W1716174983 cites W2085115437 @default.
• W1716174983 cites W2085608646 @default.
• W1716174983 cites W2086107881 @default.
• W1716174983 cites W2086787508 @default.
• W1716174983 cites W2090998770 @default.
• W1716174983 cites W2093421538 @default.
• W1716174983 cites W2095566533 @default.
• W1716174983 cites W2103581484 @default.
• W1716174983 cites W2104582585 @default.
• W1716174983 cites W2105454690 @default.
• W1716174983 cites W2106703642 @default.
• W1716174983 cites W2120061155 @default.
• W1716174983 cites W2128883244 @default.
• W1716174983 cites W2134682467 @default.
• W1716174983 cites W2147814753 @default.
• W1716174983 cites W2152299618 @default.
• W1716174983 cites W2155772701 @default.
• W1716174983 cites W2164346890 @default.
• W1716174983 cites W2167465010 @default.
• W1716174983 cites W2171216596 @default.
• W1716174983 cites W2180583964 @default.
• W1716174983 cites W2319279040 @default.
• W1716174983 cites W4376595506 @default.
• W1716174983 cites W2327820741 @default.
• W1716174983 doi "https://doi.org/10.1089/ars.2014.6043" @default.
• W1716174983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25977985" @default.
• W1716174983 hasPublicationYear "2015" @default.
• W1716174983 type Work @default.
• W1716174983 sameAs 1716174983 @default.
• W1716174983 citedByCount "17" @default.
• W1716174983 countsByYear W17161749832017 @default.
• W1716174983 countsByYear W17161749832018 @default.
• W1716174983 countsByYear W17161749832019 @default.
• W1716174983 countsByYear W17161749832020 @default.
• W1716174983 countsByYear W17161749832021 @default.
• W1716174983 countsByYear W17161749832022 @default.
• W1716174983 countsByYear W17161749832023 @default.
• W1716174983 crossrefType "journal-article" @default.
• W1716174983 hasAuthorship W1716174983A5005163834 @default.

• next