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- W1716314675 abstract "We have developed a mathematical model for the sarcolemmal Ca/sup 2+/ current and the cytosolic Ca/sup 2+/ transient in a rat ventricular myocyte based on recent experimental data. A lumped fluid-compartment model is developed that includes separate multi-state kinetic models for the L-type Ca/sup 2+/ current (I/sub Ca,L/) of the sarcolemma (SL) and the ryanodine-sensitive Ca/sup 2+/ current (I/sub release/) of the sarcoplasmic reticulum (SR). The cleft space volume between the SL and SR is divided into three sub-compartments and material balances for Ca/sup 2+/ are provided for each compartment. A relatively large cytosolic compartment containing Ca/sup 2+/ buffers (calmodulin, troponin) is also provided and the SR is modeled in terms of individual longitudinal uptake, transfer and release compartments. Calcium buffering is also provided in the Ca/sup 2+/ release compartment (calsequestrin). The lumped model can accurately simulate the family of I/sub Ca,L/ waveforms and associated cytosolic Ca/sup 2+/ transients from voltage clamp studies of the isolated rat ventricular cell. Implicit in the model is a description of calcium-induced calcium-release (CICR). The model also simulates a number of important features of excitation-contraction coupling including: (a). graded Ca/sup 2+/-release, (b). voltage- and Ca/sup 2+/-dependent inactivation of I/sub Ca,L/, and (c). Ca/sup 2+/-dependent inactivation of I/sub release/." @default.
- W1716314675 created "2016-06-24" @default.
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- W1716314675 date "2003-01-20" @default.
- W1716314675 modified "2023-09-27" @default.
- W1716314675 title "A model of sarcolemmal Ca/sup 2+/ current and cytosolic Ca/sup 2+/ transient in a rat ventricular cell" @default.
- W1716314675 doi "https://doi.org/10.1109/iembs.1999.802176" @default.
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