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- W1716757788 abstract "Summary: Flow cytometry is the method of choice for the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). It allows the quantitative measurement of the glycosylphosphatidyl-inositol-anchored proteins (GPI-AP) which are deficient on hematopoietic cells in this acquired stem cell disorder. It is a rapid and easy diagnostic procedure which can be applied to all hematopoietic cell lineages. However, some important pitfalls of this method have to be considered. We propose a panel of cells and GPI-AP for safe diagnosis of PNH. Zusammenfassung: Die Durchflußzytometrie ist die Methode der Wahl für die Diagnose der paroxysmalen nächtlichen Hämoglobinurie (PNH). Diese Methode erlaubt die quantitative Messung der Glycosylphosphatidyl-Inositol verankerten Proteine (GPI-AP), welche auf den hämatopoietischen Zellen bei dieser Stammzellkrankheit fehlen. Es ist ein schnelles und einfaches diagnostisches Verfahren, welches auf alle hämatopoetischen Zellreihen angewandt werden kann. Jedoch müssen einige wichtige Problemstellen bei dieser Methode beachtet werden. Wir schlagen ein Spektrum von Zellen und GPI-AP für die sichere Diagnose der PNH vor." @default.
- W1716757788 created "2016-06-24" @default.
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- W1716757788 date "2003-07-01" @default.
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- W1716757788 title "Flow Cytometric Analysis of GPI-deficient Cells for the Diagnosis ofParoxysmal Nocturnal Hemoglobinuria (PNH). Durchflusszytometrische Analyse GPI-defizienter Zellen zur Diagnose der paroxysmalen nachtlichen Hamoglobinurie (PNH)" @default.
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- W1716757788 doi "https://doi.org/10.1046/j.1439-0477.2003.03046.x" @default.
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